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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
ARHGAP18AntibodyPropertiesDescription Anti-ARHGAP18(RABBIT)Antibody-600-401-Y58 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application ELISA:1:10,000-1:20,000 IFMicroscopy:20µg/mL WesternBlot:1-2µg/mL OtherDilution:Immunocytochemistry:2.5µg/mL PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName ARHGAP18 RelevantLinks UniProtKB-Q8N392 GeneID-93663 NCBI-NP_277050 |
ARHGAP18AntibodyDescription
Background
ARHGAP18isonememberofthehumanRhoGAPfamilywithapproximately80RhoGAPproteinsknowntobeencodedinthehumangenome.RhoproteinsbelongtotheRassuperfamilythatiscomposedofover50membersdividedintosixfamilies,includingRas,Sar,Rho,Ran,RabandArf.RhoGTPasesareimportantregulatorsoftheactinCytoskeletonandconsequentlyinfluencetheshapeandmigrationofcells.ARHGAP18islinkedtoRas,andthus,toEGFR-mediatedproliferation,migrationanddifferentiation.ARHGAP18ispreciselycontainedwithinchromosome6q22-24,whichhasbeenshowntobelinkedtoschizophrenia,suggestingthatARHGEP18mayplayaroleinthiscondition.
Synonyms
ARHGAP18Antibody,SENEX,MacGAP,bA307O14.2,RhoGTPase-activatingprotein18
Immunogen
Anti-ARHGAP18antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha15aminoacidsyntheticpeptideneartheC-terminusofhumanARHGAP18.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-ARHGAP18AntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunocytochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately75kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-ARHGAP18Antibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithARHGAP18fromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.