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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
ARCAntibodyPropertiesDescription Anti-ARC(RABBIT)Antibody-600-401-Y56 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application ELISA:1:50,000 WesternBlot:1:5,000 PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName NOL3 RelevantLinks UniProtKB-O60936 GeneID-8996 NCBI-NP_003937 |
ARCAntibodyDescription
Background
Apoptosisisregulatedbydeathdomain(DD)and/orcaspaserecruitmentdomain(CARD)containingmoleculesandacaspasefamilyofproteases.CARDcontainingcelldeathregulatorsincludeRAIDD,RICKBCL10,Apaf-1,caspase-9,andcaspase-2.AnovelCARDdomaincontainingproteinwasrecentlyidentifiedanddesignatedARCforapoptosisrepressorwithCARD.ARCinteractswithcaspase-2and-8andinhibitsenzymaticactivityofcaspase-8.ARCsuppressesapoptosisinducedbycelldeathadaptersFADDandTRADDandbycelldeathreceptorsFas,TNFR-1,andDR3.ThemessengerRNAofARCisprimarilyexpressedinskeletalmuscleandcardiactissue.
Synonyms
ARCAntibody,ARC,FCM,MYP,NOP,NOP30,ARC,Nucleolarprotein3,ApoptosisrepressorwithCARD,Myp
Immunogen
Anti-ARCantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha17aminoacidpeptideneartheN-terminusofhumanARC.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-ARCAntibodyhasbeentestedforuseinELISAandWesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately24kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-ARCAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithARCfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.