Rockland/Aquaporin 2 phospho S269 Antibody/612-401-D10/100 µL

价格
¥7100.00
货号:612-401-D10
浏览量:127
品牌:Rockland
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商品描述

Aquaporin2phosphoS269AntibodyProperties

Description
Anti-Aquaporin2pS269(Rabbit)Antibody-612-401-D10
Host
Rabbit
TargetSpecies
Rat
KnownCrossReactivity
rat
Clonality
Polyclonal
Application
ELISA:1:10,000
WesternBlot:1:1000
PhysicalState
Liquid
ShippingCondition
DryIce
Format
IgG
Label
Unconjugated
Buffer
0.01MHEPES,0.15MSodiumChloride,pH7.5
StABIlizer
0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)Glycerol
GeneName
AQP2
RelevantLinks
UniProtKB-P34080
GeneID-25386
UniProtKB-P34080.1

Aquaporin2phosphoS269AntibodyDescription

Background
Aquaporin2antibodyrecognizesaquaporin2(AQP2)whichisahormonallyregulatedwaterchannellocatedintherenalcollectingduct.MutationsintheAQP2genecausehereditarynephrogenicdiabetesinsipidusinhumans.AvasopressininducedcAMPincreaseresultsinthephosphorylationofAQP2atserine-256anditstranslocationfromtheintracellularvesiclestotheapicalmembraneofprincipalcells.Serine-269hasbeenrecentlyidentifiedasavasopressin-mediatedphosphorylationsiteonAQP2andassuchhasshowntopotentiateplasmamembraneretentionofAQP2.Anti-Aquaporin2pS269antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.
Synonyms
ADHwaterchannel,Aquaporin-CD,Collectingductwaterchannelprotein,WCH-CD,Waterchannelproteinforrenalcollectingduct
Immunogen
Anti-Aquaporin2pS269Antibodywasproducedbyrepeatedimmunizationswithsyntheticphospho-peptidecorrespondingtoaminoacidresiduessurroundingSer269.
ImmunogenType
Peptide
PostTranslationalModification
Phosphorylation
StorageCondition
Storevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-Aquaporin2pS269antibodyissuitableforuseinELISA,WesternBlotting.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandofapproximately29kDainsizecorrespondingtoAQP2proteinphosphorylatedatSer269intheappropriatecelllysateorextract.Thisantibodyalsorecognizestheglycosylatedformofaquaporin2proteinatapproximately37kDainsize.
Purity/Specifity
Anti-Aquaporin2pS269AntibodyisdirectedagainstratAquaporin2proteinsphosphorylatedatS269.Theantibodywaspreparedfrommonospecificantiserumbyimmunoaffinitychromatographyusingphosphopeptidecoupledtoagarosebeadsfollowedbysolidphaseadsorption(s)againstnon-phosphopeptideandnon-specificpeptidetoremoveanyunwantedreactivities.Assaybyimmunoelectrophoresisresultedinasingleprecipitinarcagainstanti-RabbitSerum.Minimalreactivityoccursagainstnon-phosphorylatedAquaporin2.ReactivityagainstAquaporin2occursfromratsources.However,reactivityisalsoexpectedagainstthefollowingspeciesbasedon100%sequencehomology:bovine,canineandmouse.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
Rockland Immunochemicals,Inc.(Rockland)成立于1962年,是一家全球生物技术公司,致力于为功能基因组学,基因治疗和药物发现市场的基础,应用和临床研究提供领先的工具。Rockland是一家私有公司,在美国宾夕法尼亚州费城附近拥有一家具有抗体和蛋白质生产能力的制造工厂。高度专业化的主要分销商网络为全球市场提供支持。我们的实验室面积超过60,000平方英尺,生产抗体和基于抗体的工具,这些工具用于帮助定义与细胞功能和疾病相关的机制。我们的声誉建立在对细节,客户服务的关注以及对开发世界一流产品线所需的工具和技术的持续投资上。我们了解并赞赏我们的产品如何帮助解决生命科学研究中的重大全球性问题。在产品进入任何研究实验室之前,我们会非常谨慎地进行验证。每个产品的每批产品都在我们自己的工厂中经过严格的质量控制测试和多重分析验证,以确保性能稳定。