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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
APRILAntibodyProperties Description Anti-APRIL(RABBIT)Antibody-600-401-G77 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,Mouse Clonality Polyclonal Application WesternBlot:1-4ug/ml PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide GeneName TNFSF13 RelevantLinks NCBI-NP_003799 UniProtKB-O75888 GeneID-8741 |
APRILAntibodyDescription
Background
APRILAntibodydetectsofhumanAPRIL.MembersintheTNFsuperfamilyregulateimmuneresponsesandinduceapoptosis.AnovelmemberintheTNFfamilywasrecentlyidentifiedbyseveralgroupsanddesignatedAPRIL(foraproliferation-inducingligand),TALL-2(forTNF-andApoL-relatedLeukocyte-expressedLigand2),andTRDL-1alpha(forTNFrelateddeathligand1alpha)inhumanandmouse.TworeceptorsforAPRILwererecentlyidentifiedanddesignatedTACIandBCMA.APRILstimulatesBandTcellproliferation,triggershumoralimmuneresponses,activatesNF-kappaB,andinducescelldeath.APRILanditscloserelativeofBlySandtheirreceptorsBCMAandTACIareinvolvedindiseasesofautoimmunityandcancer.Anti-APRILantibodiesareidealforinvestigatorsinvolvedinCancerandNFkappaBresearch.
Synonyms
APRIL,TALL2,ZTNF2
Immunogen
APRILAntibodywasproducedfromwholerabbitserumpreparedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacidswithinaextracellulardomainofhumanAPRIL.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-APRILAntibodyissuitableforuseinE,WB,andIHC.Expectabandapproximately~27.4kDaonspecificlysates.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.
Purity/Specifity
Anti-APRILAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitypurification.ABLASTanalysiswasusedtosuggestcross-reactivitywithAPRILwithHumanandMousebasedon100%homologywiththeimmunizingsequence.Cross-reactivitywithAPRILfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitABIlityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
