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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
APPAntibodyProperties Description Anti-APP(RABBIT)Antibody-600-401-Y51 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName APP RelevantLinks UniProtKB-P05067 GeneID-351 NCBI-CAA30050 |
APPAntibodyDescription
Background
Accumulationoftheamyloid-betapeptide(Abeta)inthecerebralcortexisacriticaleventinthepathogenesisofAlzheimer"sdisease.Thebeta-amyloidproteinprecursor(APP)iscleavedbyoneoftwobeta-secretases(BACEandBACE2),producingasolublederivativeoftheproteinandamembraneanchored99-aminoacidcarboxy-terminalfragment(C99).TheC99fragmentservesassubstrateforgamma-secretasetogeneratethe4kDaamyloid-betapeptide(Abeta),whichisdepositedintheAlzheimer"sdiseasepatient"sbrains.Recently,DeathReceptor6(DR6)wasfoundtointeractwithanamino-terminalfragmentoftheBeta-amyloidprotein(N-APP)inneurons,activatingacaspase6-dependentapoptoticeventleADIngtoaxonaldegenerationandpruningduringdevelopment,suggestingthatthesetwoproteinsareinvolvedinneuraldevelopmentandmaypossIBLyplayaroleinAlzheimer"sdisease.
Synonyms
APPAntibody,AAA,AD1,PN2,ABPP,APPI,CVAP,ABETA,PN-II,CTFgamma,A4,AmyloidbetaA4protein,APP
Immunogen
Anti-APPantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithan18aminoacidsyntheticpeptideneartheN-terminusofhumanAPP.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-APPAntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunohistochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately87kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-APPAntibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.CrossreactivitywithAPPfromothersourceshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
