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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
ApolipoproteinJAntibodyProperties Description Anti-ApolipoproteinJ(GOAT)Antibody-600-101-198 Host Goat TargetSpecies Human KnownCrossReactivity human Clonality Polyclonal Application ELISA:1:5,000-1:10,000 WesternBlot:1:5,000-1:10,000 Immunohistochemistry:1:50-1:200 ImmunoPrecipitation:1:100 OtherDilution:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition WetIce Format IgG Label Unconjugated Concentration 1.0mg/mLbyUVabsorbanceat280nm Buffer 0.125MSodiumBorate,0.075MSodiumChloride,0.005MEDTA,pH8.0 Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName CLU,APOJ,CLI,KUB1 RelevantLinks UniProtKB-P10909 NCBI-P10909.1 GeneID-1191 |
ApolipoproteinJAntibodyDescription
Background
ApolipoproteinJAntibodyfunctionsasasecretedchaperonethatpreventsaggregationofnonnativeproteins.Itpreventsstress-inducedaggregationofbloodplasmaproteinsandinhibitstheformationsofamyloidfibrils.ApolipoproteinJdoesnotrequireATPorrefoldproteinsbyitself.Itmaintainspartiallyunfoldedproteinsinastateforsubsequentrefoldingbyotherchaperones.ItisshowntobeinvolvedinseveralbasicBIOLOGicaleventssuchascelldeath,tumorprogression,andneurodegenerativedisorders.Bindingtocellsurfacereceptorsittriggersinternalizationofchaperone-clientcomplexandsubsequentlysosomalorproteasomaldegradation.ItmodulatesNF-kappa-Btranscriptionalactivity.NuclearisoformspromoteapoptosiswhilemitochondrialisoformssuppressBAX-dependentreleaseofcytochromecintothecytoplasmandinhibitapoptosis.Anti-ApolipoproteinJAntibodyisusefulforresearchersinterestedintheimmunesystem,Ubiquitinpathways,andcardiovascularresearch.
Synonyms
goatanti-ApolipoproteinJantibody,Clusterin,Complement-associatedproteinSP-40,Complementcytolysisinhibitor,CLI,NA1/NA2,Apo-J,Testosterone-repressedprostatemessage2,TRPM-2,Ku70-bindingprotein1,Aging-associatedgene4protein,Clusterinbetachain,Clusterinalphachain,Complementcytolysisinhibitorachain,Complementcytolysisinhibitorbchain,ApoJalpha,ApoJbeta,CLU,CLI,KUB1,AAG4
Immunogen
apoLipoproteinTypeJwasisolatedfromhumanplasmabydensitygrADIentcentrifugationfollowedbyHPLCpurification.
ImmunogenType
NativeProtein
StorageCondition
Storevialat4°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Diluteonlypriortoimmediateuse. Forextendedstoragemixwithanequalvolumeofglycerol,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.
ApplicationNote
Anti-apolipoproteinantibodieshavebeenusedforindirecttrappingELISAforquantitationofantigeninserumusingastandardcurve,forimmunoprecipitationandforwesternblottingforhighlysensitivequalitativeanalysis.
Purity/Specifity
Thisproducthasbeenpreparedbyimmunoaffinitychromatographyusingimmobilizedantigensfollowedbyextensivecross-adsorptionagainstotherapoLipoproteinsandhumanserumproteinstoremoveanyunwantedspecificities. Typicallylessthan1%crossreactivityagainstothertypesofapoLipoproteinwasdetectedbyELISAagainstpurifiedstandards. ThisantibodyreactswithhumanapoLipoproteinJandhasnegligIBLecross-reactivitywithTypeA-I,A-II,B,C-I,C-II,C-IIIandEapoLipoproteins. Specificcrossreactionofanti-apoLipoproteinantibodieswithantigensfromotherspecieshasnotbeendetermined. Non-specificcrossreactionofanti-apoLipoproteinantibodieswithotherhumanserumproteinsisnegligible.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
