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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
APOBEC3BAntibodyProperties Description Anti-APOBEC3B(RABBIT)Antibody-600-401-Y46 Host Rabbit TargetSpecies Human KnownCrossReactivity Human,mouse,rat Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1mg/mLbyUVabsorbanceat280nm Buffer 0.01MSodiumPhosphate,0.25MSodiumChloride,pH7.2 Preservative 0.02%(w/v)SodiumAzide StABIlizer None GeneName APOBEC3B RelevantLinks UniProtKB-Q9UH17 GeneID-9582 NCBI-NP_004891 |
APOBEC3BAntibodyDescription
Background
TheApolipoproteinBmRNA-editing,enzyme-catalytic,polypeptide-like(APOBEC)3isamulti-isoformmemberofthecytosinedeaminasefamilyofenzymesthatactonmonomericnucleosideandnucleotidesubstrates(1).SimilartoTRIM5?whichtargetsincomingretroviralcapsids,APOBEC3playsamajorroleincellulardefenseagainstretroviralinfection(2,3).APOBEC3Bhasalsobeenshowntobeupregulatedinseveralcancers;itisthoughtthatAPOBEC3B-catalyzedgenomicuracillesionsareresponsIBLeforalargeproportionofmutationsinmultipledistinctcancers(4).
Synonyms
APOBEC3BAntibody,A3B,ARP4,ARCD3,PHRBNL,APOBEC1L,bK150C2.2,DJ742C19.2Phorbolin-1-relatedprotein,A3B
Immunogen
Anti-APOBEC3Bantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswitha14aminoacidpeptideneartheN-terminusofhumanAPOBEC3B.
ImmunogenType
Peptide
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-APOBEC3BAntibodyhasbeentestedforuseinELISA,WesternBlotting,ImmunohistochemistryandImmunofluorescence.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectabandatapproximately46kDainWesternBlotsofspecificcelllysatesandtissues.
Purity/Specifity
Anti-APOBEC3Bantibodywasaffinitypurifiedfrommonospecificantiserumbyimmunoaffinitychromatography.APOBEC3Bantibodyishuman,mouseandratreactive.AtleastthreeisoformsofAPOBEC3Bareknowntoexist;thisantibodywilldetectallthree.APOBEC3Bantibodymaycross-reactwithAPOBEC3D.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
