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品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
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商品描述
Anti-GAB1AntibodyProperties![]() Description Anti-GAB1(RABBIT)Antibody-200-401-G66 Host Rabbit TargetSpecies Human KnownCrossReactivity human Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1.02mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName GAB1 RelevantLinks GeneID-2549 |
Anti-GAB1AntibodyDescription
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Background
GAB1antibodydetectsGAB1whichisamemberoftheIRS1-likemultisubstratedockingproteinfamily.Theproteinisanimportantmediatorofbranchingtubulogenesisandplaysacentralroleincellulargrowthresponse,transformationandapoptosis.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.GAB1playsaroleinintracellularsignalingcascadestriggeredbyactivatedreceptor-typekinases.ItisknowntoplayaroleinFGFR1signalingandisprobablyinvolvedinsignalingbytheepidermalgrowthfactorreceptor(EGFR)andtheinsulinreceptor(INSR).GAB1interactswithGRB2andwithotherSH2-containingproteins.ItisknowntointeractwithphosphorylatedLAT2,PTPRJ,FRS2,GRB2,PIK3R1andSOS1.GAB1getsphosphorylatedinresponsetoFGFR1activation.ThistyrosinephosphorylationofGAB1mediatesinteractionwithseveralproteinsthatcontainSH2domains.Anti-GAB1AntibodyisidealforinvestigatorsinvolvedinCellSignaling,Cancer,NeuroscienceandSignalTransductionresearch.
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Synonyms
rabbitAnti-GAB1Antibody,GAB1,GAB-1,GRB2-associated-bindingprotein1,GRB2-associatedbinder1,Growthfactorreceptorboundprotein2-associatedprotein1
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Immunogen
Anti-GAB1AntibodywasproducedinrabbitsbyrepeatedimmunizationswitharecombinantproteinproducedinSf9cellscorrespondingtothefulllengthhumanGABprotein.
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ImmunogenType
RecombinantProtein
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StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
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ApplicationNote
Anti-GAB1AntibodyhasbeentestedforuseinELISAandbywesternblot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectapredominantbandat76.6kDabywesternblottingintheappropriatecelllysateorextract.
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Purity/Specifity
Anti-GAB1antibodyisdirectedagainsthumanGAB1.Theantibodydetectsbothunphosphorylatedandphosphorylatedformsoftheprotein.Anti-GAB1antibodywaspurifiedfromrabbitserumbyProteinAchromatographyfollowedbycrossadsoption.CrossreactivitywithGAB1fromotherspecieshasnotbeendetermined.
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DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
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