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公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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https://www.ebiomall.com
商品描述
Anti-GAB1AntibodyProperties Description Anti-GAB1(RABBIT)Antibody-200-401-G66 Host Rabbit TargetSpecies Human KnownCrossReactivity human Clonality Polyclonal Application PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format IgG Label Unconjugated Concentration 1.02mg/mLbyUVabsorbanceat280nm Buffer 0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2 Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName GAB1 RelevantLinks GeneID-2549 |
Anti-GAB1AntibodyDescription
Background
GAB1antibodydetectsGAB1whichisamemberoftheIRS1-likemultisubstratedockingproteinfamily.Theproteinisanimportantmediatorofbranchingtubulogenesisandplaysacentralroleincellulargrowthresponse,transformationandapoptosis.Twotranscriptvariantsencodingdifferentisoformshavebeenfoundforthisgene.GAB1playsaroleinintracellularsignalingcascadestriggeredbyactivatedreceptor-typekinases.ItisknowntoplayaroleinFGFR1signalingandisprobablyinvolvedinsignalingbytheepidermalgrowthfactorreceptor(EGFR)andtheinsulinreceptor(INSR).GAB1interactswithGRB2andwithotherSH2-containingproteins.ItisknowntointeractwithphosphorylatedLAT2,PTPRJ,FRS2,GRB2,PIK3R1andSOS1.GAB1getsphosphorylatedinresponsetoFGFR1activation.ThistyrosinephosphorylationofGAB1mediatesinteractionwithseveralproteinsthatcontainSH2domains.Anti-GAB1AntibodyisidealforinvestigatorsinvolvedinCellSignaling,Cancer,NeuroscienceandSignalTransductionresearch.
Synonyms
rabbitAnti-GAB1Antibody,GAB1,GAB-1,GRB2-associated-bindingprotein1,GRB2-associatedbinder1,Growthfactorreceptorboundprotein2-associatedprotein1
Immunogen
Anti-GAB1AntibodywasproducedinrabbitsbyrepeatedimmunizationswitharecombinantproteinproducedinSf9cellscorrespondingtothefulllengthhumanGABprotein.
ImmunogenType
RecombinantProtein
StorageCondition
Storevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-GAB1AntibodyhasbeentestedforuseinELISAandbywesternblot.Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectapredominantbandat76.6kDabywesternblottingintheappropriatecelllysateorextract.
Purity/Specifity
Anti-GAB1antibodyisdirectedagainsthumanGAB1.Theantibodydetectsbothunphosphorylatedandphosphorylatedformsoftheprotein.Anti-GAB1antibodywaspurifiedfromrabbitserumbyProteinAchromatographyfollowedbycrossadsoption.CrossreactivitywithGAB1fromotherspecieshasnotbeendetermined.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
