品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Anti-DDB1AntibodyProperties Description Anti-p127-DDB1(internal)(RABBIT)Antibody-100-401-A09 Host Rabbit TargetSpecies Human KnownCrossReactivity human,mouse Clonality Polyclonal Application ELISA:1:2,000-1:10,000 WesternBlot:1:500-1:1,000 Immunohistochemistry:UserOptimized ImmunoPrecipitation:1:500 OtherDilution:UserOptimized PhysicalState Liquid(sterilefiltered) ShippingCondition DryIce Format Antiserum Label Unconjugated Concentration 85mg/mLbyRefractometry Buffer None Preservative 0.01%(w/v)SodiumAzide StABIlizer None GeneName DDB1 RelevantLinks UniProtKB-Q16531 NCBI-148529014 GeneID-1642 |
Anti-DDB1AntibodyDescription
Background
DDB1isalsoknownasdamage-specificDNAbindingprotein1,DDBp127subunit,DDBa,UV-damagedDNA-bindingprotein1,UV-DDB1,XerodermapigmentosumgroupEcomplementingprotein,XPCe,X-associatedprotein1andXAP-1. TheDDB1geneencodesthelargesubunit(p127)ofDNAdamage-bindingprotein,whichisaheterodimer,composedofalargeandasmallsubunit(p48DDB2).Thisnuclearproteinfunctionsinnucleotide-excisionrepairresultingfromUV-damagedDNAbybindingtopyrimidinedimers. ItsdefectiveactivitycausestherepairdefectinthepatientswithxerodermapigmentosumcomplementationgroupE(XPE).XP-Eisararehumanautosomalrecessivediseasecharacterizedbysolarsensitivity,highpredispositionfordevelopingcancersonareasexposedtosunlightand,insomecases,neurologicalabnormalities. DDB1antibodyisinvolvedinEpigeneticandCancer/DNADamageresearch.
Synonyms
rabbitanti-Anti-p127-DDB1antibody,DamagespecificDNAbindingprotein1antibody,DDB1antibody,DDBp127subunitantibody,DDBaantibody,DNAdamagebindingprotein1antibody,UVdamagedDNAbindingfactorantibody
Immunogen
DDB1antibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids198-213ofHumanDDB1(internal)coupledtoKLH.
ImmunogenType
Peptide
StorageCondition
StoreAnti-DDB1at-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.
ApplicationNote
Anti-DDB1antibodyreactswithhumanandmouse DDB1bywesternblotandimmunoprecipitation. Theantibodyimmunoprecipitatesinvitrotranslatedproteinandproteinfromcelllysates(usingHeLa,NIH-3T3,andothers). Coimmunoprecipitationofrelatedproteinshasnotbeentested. A127.0kDabandcorrespondingtohumanDDB1isdetected. MostcelllinesexpressingDDB1canbeusedasapositivecontrol. Researchersshoulddetermineoptimaltitersforotherapplications.
Purity/Specifity
Anti-DDB1ismonospecificantiserumprocessedbydelipidationanddefibrinationfollowedbysterilefiltration.ThisproductreactswithhumanandmouseDDB1. CrossreactivitywithDDB1fromothersourcesisnotknown.
DisclaimerNote-General
Thisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.
