品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Description:uPAR(D2domain),Human,mAbIIIB11
MonoclonalantibodyIIIB11recognizestheurokinase-typeplasminogenactivatorreceptor(uPARorCD87),aGPIanchoredhighlyglycosylated,single-chainpolypeptide.CD87,a45-to60-kDprotein,consistsofthreestructurallyhomologousdomainsofapproximately90aminoacids,designatedD1,D2,andD3,eachcontainingaconservedarrangementofdisulfidebondsandseparatedbyshortinterdomainlinkersequences.uPARexistsinvariousmolecularforms;heavilyglycosylated,acleavedform,asolubleformandsplicedforms.CD87isexpressedbymonocytes/macrophages,neutrophils,endothelial,smoothmusclecellsandepithelialcells.CD87isoverexpresseduponexposuretoinflammatorymediators.Theproteinisalsohighlyexpressedbytumorcellsandcontributestotheirinvasivenessandmetastaticpotential.CD87isamultiligandreceptorthatoperatesasakeyelementinpathophysiologicalprocessesinvolvingcellmigrationandtissueremodellingduringinflammationandcancermetastasis.CD87bindswithhighaffinitytheSer-proteinaseurokinase-typeplasminogenactivator(uPA)which,uponbindingcatalyzestheconversionofplasminogenintoplasminwhichactivatesvariousmatrixmetalloproteinaseleADIngtoahighpotentialforpericellularproteolysis.CD87functionsalsoasanadhesionmoleculebybindingvitronectin,thuscontributingtoleukocyticadherence.High-affinitybindingofCD87tobothuPAandvitronectinrequiresthepresenceofdomain1(D1).Yet,CD87participatesincelladherenceandmigrationalsothroughtwootherroutes,aphysicalassociationandfunctionalinteractionwithvariousintegrinsandviaanintrinsicchemotacticactivityassociatedtotheD1-D2linkersequence.MonoclonalantibodyIIIB11recognizesD2oftheurokinase-typeplasminogenactivatorreceptor(CD87).Theantibodyrecognizesaminoacidsequences125-132oftheD2domain.
Specifications:
Catalognumber | HM2143 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Frozensections,Paraffinsections,Westernblot |
Use | Forimmunohistochemistry,flowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
Isotype | MouseIgG1 |
Species | Human |
Alias | uPA,CD87,ClusterofDifferentiation87 |
References | 1.Luther,Tetal;Epitope-mappedmonoclonalantibodiesastoolsforfunctionalandmorphologicalanalysesofthehumanurokinasereceptorintumortissue.AmJPathol1997,150:1231 |
StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Tumorimmunology |