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商品描述
Description:CD96,Human,mAbNK92.39
ThemonoclonalantibodyNK92.39reactswithCD96,alsoknownasTcell-activatedincreasedlateexpression(Tactile).CD96promotesnaturalkiller(NK)celladhesiontotargetcellsexpressingthepoliovirusreceptor(PVRorCD155).FurThermoreCD96stimulatescytotoxicityofactivatedNKcells,andmediatesacquisitionofPVRfromtargetcells.ThismeansNKcellshaveduetothereceptorCD96adualreceptorsystemthatrecognizesnectinsandnectin-likemoleculesontargetcellsandmediatesNKcellsadhesionandtriggeringofeffectorfunctions.AsPVRishighlyexpressedincertaintumors,thisreceptorsystemmaybecriticalforNKcellrecognitionoftumors.ThemonoclonalantibodyNK92.39blocksbindingofsolublepoliovirusreceptor(PVR)toNK92cells.
Specifications:
Catalognumber | HM2210 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Functionalstudies |
Use | Forflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForfunctionalstudiesinvitrodilutionshavetobemadeaccordingtotheamountsofCD96tobeinactivated. |
Isotype | MouseIgG1 |
Species | Human |
References | Fuchs,Aetal;Cuttingedge:CD96(Tactile)promotesNKcell-targetcelladhesionbyinteractingwiththepoliovirusreceptor(CD155).JImmunol2004,172:3994 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Tumorimmunology |