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Hycult Biotech/TLR9, Human, antagonist (ODN A151) | Hycult Biotech/HC4076-01

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¥2740.00
货号:HC4076-01
浏览量:127
品牌:Hycult Biotech
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TLR9 antagonist HC4076 is an ODN used to inhibit preferably human Toll-like receptor 9. HC4077 can be used as control reagent. Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called ‘pathogen-associated molecular patterns’. Activation of TLRs leads to activation of NFκB-dependent and IFN regulatory factor-dependent signaling pathways. TLRs are differentially expressed among tissues and cell types by various cells of the immune system, such as macrophages and dendritic cells. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens.Whereas most TLRs are expressed on the cell surface, TLR9 is expressed intracellularly within one or more endosomal compartments and recognizes nucleic acids. TLR9 detects a rather subtle difference in the DNA of vertebrates compared with that of pathogens. Vertebrate genomic DNAs have mostly methylated CpG dinucleotides where bacterial and viral DNAs have unmethylated CpG dinucleotides. TLR9 undergoes relocation from endoplasmic reticulum to CpG-ODN-containing endosomes. In these endosomes TLR9 becomes a functional receptor after proteolytic cleavage. TLR9 exists as a preformed homodimer and CpG-ODN binding promotes its conformational change, bringing the cytoplasmic TIR-like domains close to each other. This allows a recruitment of the key adapter protein MyD88 which initiates a signaling cascade.Certain DNA sequences can suppress innate immune activation and have been shown to be effective in eg arthritis and SLE. The TTAGGG repeat is such sequence and is commonly found in mammalian telomeric DNA. Suppressive synthetic ODNs prevent TLR9 activation by binding to unmethylated CpG DNA. ODN A151 functions as a competitive inhibitor by binding to AIM2 and IFI16 and competing with these sensors for stimulatory DNA ligands.
Hycult Biotech当您在研究项目中寻找中小企业合作伙伴时,Hycult Biotech是您的首选合作伙伴。凭借我们的背景和专业知识,我们可以为您的项目增值:从成为财团的负责人到成为科学项目的推动力,我们都有在科学项目中扮演不同角色的经验。由于我们遍布全球的广泛网络,我们可以在寻找研究项目的合作伙伴方面发挥核心作用。我们可以协助撰写建议书或建立财团。获得科学资助的我们的研究活动示例:生物标志物测定法的发展抗体的表征。从概念到最终产品。Hycult Biotech代表什么从1994年开始创建分析,抗体和蛋白质。根据ISO13485指南开发和生产(IVD)套件。关于复杂基质中蛋白质难以测量的广泛知识。制药和生物技术行业的伴侣诊断合作伙伴。 Hycult Biotech目前参与以下研究项目OPZuid:Zuid-Nederland行动纲领Hycult Biotech利用“ OP Zuid”资金,目前正在研究开发针对类风湿性关节炎和骨关节炎的创新诊断测试的可能性。使用该测试可以更好地监视患者及其疾病活动,严重程度和治疗反应。更好的诊断结合个性化治疗将大大改善这些患者的生活质量。相关:缓解慢性自身免疫性疾病的预防RELENT项目提供了探索新的研究领域并加深其对自身免疫和炎症领域的见解的机会。Hycult Biotech在该主题非常适合的慢性炎性疾病领域中不断扩展产品。寻找与RA,IBD和AASV相关的新型靶蛋白将为进一步进入诊断领域提供机会。 Hycult Biotech已成功参与以下研究项目-DIREKT:解除血管内固有免疫反应,改善慢性肾脏病的治疗方式-PREDICCt:糖尿病和与糖尿病相关的心血管并发症的预测和早期诊断的生物标志物-TranSVIR:转化为血管炎症和修复的科学-指示:慢性自身免疫的传染性诱因 有关科学赠款和合作的更多信息,请参见以下传单: