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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Description:Spi-6,Mouse,pAb
ThepolyclonalantibodyrecognizesmouseSpi-6,alsoknownasserpinB9,acytoplasmicserineproteaseinhibitorof~42kD.Spi-6isexpressedindendriticcells,lymphocytesandspecificcelltypesatimmune-privilegedsites.ItinactivatesgranzymeB,anaturaloccurringinducerofprogrammedcelldeath.Assuch,Spi-6functionsasanti-apoptoticprotein.IncytotxicTcells(CTL),Spi-6isrequiredtoprotectclonalbursts(expansion)fromgranzymeBinducedcelldeath.However,itisnotrequiredforthedevelopmentofmemorycells.ExpressionofSPI-6isofcrucialimportanceintheescapeofseveraltumorsfromaCTLresponseandis,therefore,aparameterthatinfluencesthefeasibilityofCTL-mediatedimmunotherapyofcancer.ThepolyclonalantibodyshowsnocrossreactivitywithmouseproteinsrelatedtoSpi-6.
Specifications:
Catalognumber | HP8035 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Immunoassays,Westernblot |
Use | ForflowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | RecombinantGST-Spi-6 |
Isotype | RabbitIg |
Species | Mouse |
Alias | Cytoplasmicantiproteinase3,serpinB9,PI-9 |
References | 1.Zhang,Metal;DifferentialsurvivalofcytotoxicTcellsandmemorycellprecursors.JImmunol2007,178:3483 2.Zhang,Metal;Serineproteaseinhibitor6-deficientmicehaveincreasedneutrophilimmunitytoPseudomonasaeruginosa.JImmunol2007,179:4390 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
Disease | Tumorimmunology |