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商品描述
Description:VG5Q,Mouse,pAb
ThepolyclonalantibodyreactswithmouseVG5Q,a84kDaprotein.VG5QfunctionsasanangiogenicfactorinpromotingangiogenesisandsuppressionofVG5Qexpressioninhibitsvesselformation.Angiogenicfactorsarecriticaltotheinitiationofangiogenesisandmaintenanceofthevascularnetwork.Angiogenesishasanessentialroleinpathologicalconditionssuchascancerandvariousischaemicandinflammatorydiseases.VG5Qcanbindtoendothelialcellsandpromotecellproliferation,suggestingthattheproteinmayactinanautocrinefashion.VG5QinteractswithTWEAK(alsoknownasTNFSF12),anothersecretedangiogenicfactor.VG5Qshowsstrongexpressioninbloodvesselsandissecretedwhenvesselformationisinitiated.VG5Qproteinwasdetectedmostlyinthecytoplasmandaroundthenucleiofhumanmicrovascularendothelialcells(HMVECs).FurThermoreVG5Qisdetectedinhumanumbilicalveinendothelialcells(HUVECs),humanheartfibroblast(HHF)andovariancancercells(OV-3),butlowexpressionwasdetectedinkidneycancercells(RP-45),HeLaCellsandbladdercancercells.
Specifications:
| Catalognumber | HP8017 |
|---|---|
| Producttype | Polyclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Application | Frozensections,Immunoassays,Immunoprecipitation,Paraffinsections,Westernblot |
| Use | ForWesternblottingandimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
| Isotype | RabbitIg |
| Species | Mouse |
| References | 1.Tian,Xetal;IdentificationofanangiogenicfactorthatwhenmutatedcausessusceptibilitytoKlippel-Trenaunaysyndrome.Nature2004,427:640 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Tumorimmunology |
