品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Description:C3,Mouse,pAb
ThecomplementfactorC3consistsofanalpha-andabeta-chain.C3isacentralfactorinthecomplementcascade.ItiscentraltothealternativepathwaythatleadstotheC3convertaseC3bBb.TheclassicalandmannosebindinglectinactivationpathwaysleadtotheC3convertaseC4b2a.TheseconvertasescleaveC3resultinginC3aandC3b.Furtherdegradationleadstoformationofthealpha-chainproductsC3d,C3gandC3c.C3isanacutephaseproteinthatisproducedbyawiderangeoftissuesincludingrenalepithelialcellsandhepatocytes.
Specifications:
Catalognumber | HP8012 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Frozensections,Immunofluorescence,Paraffinsections,Westernblot |
ApplicationNotes | F:SectionswerepermeABIlizedincoldacetonefor10minutes. P:EpitoperetrievalfortheFFPEsectionswasperformedusingthePT-module(LabVision)withheatinducedepitoperetrievalpH9(HIER). |
Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RabbitIg |
Species | Mouse |
Alias | ComplementcomponentC3,HSE-MSF Genename:C3 |
PositiveControl | Kidney,spleen |
References | 1.Cashman,Setal;Expressionofcomplementcomponent3(C3)fromanadenovirusleadstopathologyinthemurineretina.InvOphtVisScie2011,52:3436 2.Bengtson,Aetal;Pharmacokinetics,Tolerability,andPreliminaryEfficacyofPaquinimod(ABR-215757),aNewQuinoline-3-CarboxamideDerivative:studiesinlupus-pronemiceandamulticenter,randomized,double-blind,placebo-controlled,repeat-dose,dose-rangingstudyinpatientswithsystemiclupuserythematosus.ArthritisRheum2012,64:15793.Tati,Retal.ComplementactivationassociatedwithADAMSTS13deficiencyinhumanandmurinethromboticmicroangiopathy.JI2013,191:2184 |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases,Nephrology |