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商品描述
Description:C5,Mouse,pAb
C5isinvolvedintheactivationofthelythicpathwaywithinthecomplementsystemwhichisanimportantfactorininnateimmunity.Thecomplementpathwayscanbedividedintheactivationpathwaysandlyticpathway.TheactivationpathwaysleadviaC3tothecleavageofthefifthcomplementcomponentC5intoC5aandC5b.C5ainducessmoothmusclecontraction,increasesvascularpermeABIlity,causesdegranulationofmastcellsandbasophils,andreleaseoflysosomalenzymes.InadditionC5astimulatesthedirectedmigrationofneutrophils,eosinophils,basophilsandmonocytes.Studiesindicatethemodulationoftheacute-phaseresponseinliverandanoverallimmuneresponsebyinducingsynthesisofcytokinessuchasTNF-alpha,IL-1beta,IL-6andIL-8.C5binitiatestheassemblyofthemembraneattackcomplex(MAC)thatmediatescytolysis.
Specifications:
Catalognumber | HP8013 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
Application | Westernblot |
Use | ForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
Isotype | RabbitIg |
Species | Mouse |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases,Nephrology |