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商品描述
Description:C5L2,Mouse,pAb
TheorphanreceptorC5L2/pgpr77,whichshares35%aminoidentitywithCD88,isapromiscuouscomplementfragment-bindingprotein.C5L2bindsC5awithhighaffinitybuthasa10-foldhigheraffinityforC5adRthanCD88.C5L2alsohasanaffinityforC4aandC3a,andtheirmetabolitesC4ades-Arg,andC3ades-Arg.C3abindsatasitedistinctfromtheC5abindingsite.C5L2transfectedintocellsdoesnotsupportdegranulationorincreasesinintracellular[Ca2+]andisnotrapidlyinternalizedinresponsetoligandbinding.However,ligationofC5L2byanaphylatoxinpotentiatesthedegranulationresponsetocross-linkageofthehighaffinityIgEreceptorsuggestingthatC5L2isananaphylatoxin-bindingproteinwithuniqueligandbindingandsignallingproperties.C5L2isproposedtomediatetheacylation-stimulatingpropertiesofC3ades-Arg/ASP.C5L2isexpressedingranulocytes,inmaturedendriticcells,ADIposetissueandfibroblasts.
Specifications:
Catalognumber | HP8015 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Functionalstudies |
Use | Forflowcytometrytobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RabbitIg |
Species | Mouse |
References | 1.Cain,Setal;TheorphanreceptorC5L2hashighaffinitybindingsitesforcomplementfragmentsC5aandC5ades-Arg.JBiolChem2002,277:7165 2.Kalant,Detal;Thechemoattractantreceptor-likeproteinC5L2bindstheC3ades-Arg77/acylation-stimulatingprotein.JBiolChem2003,278:11123 3.Ohno,Metal;Aputativechemoattractantreceptor,C5L2,isexpressedingranulocyteandimmaturedendriticcells,butnotinmaturedendriticcells.MolImmunol2000,37:407 4.Huber-Lang,Metal;Changesinthenovelorphan,C5aReceptor(C5L2),duringexperimentalsepsisandsepsisinhumans.JImmunol2005,174:1104 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases,Nephrology |