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苏州工业园区生物纳米园A4#216
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商品描述
Description:TLR7,Human,pAb
ThepolyclonalantibodyrecognizeshumanToll-likereceptor7.TLRsbelongtoafamilyofproteinsthatspecificallyrecognizesandsensesmicrobialproducts.Theyarehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.LikeitscounterpartsinDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRareidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities.ThevariousTLRsexhibitdifferentpatternsofexpression.TheTLR7geneispredominantlyexpressedinlung,placenta,andspleen,andislocatedincloseproximitytoanotherfamilymember,TLR8,onhumanchromosomeX.
TLR3,7,8and9belongtoathirdclassofTLRswhicharelocalizedintracellularwheretheydetectnucleicacidsderivedfromvirusesandbacteria.TLR7isrecognizedbysinglestrandedRNAinendosomes,whichisacommonfeatureofviralgenomeswhichareinternalizedbymacrophages.TLR7proteinsarelocalizedinendosomesand/orlysosomes.Recently,ithasbeendiscoveredthatTLR3,TLR7andTLR9traffickingrequiresUNC93B1,a12-membranespanningproteinthatresidesintheendoplasmaticreticulum.MiceorcellsthatlackUNC93B1function,aredefectiveinTLR3,TLR7andTLR9signaling.AssociationofUNC93B1withTLRsintheERfacilitatestheirtransporttotheendolysosome.
NKcellsareactivatedthroughTLR7/8andreportacentralroleformonocyte-derivedIL-12inthedifferentialIFN-producedbyNKcellsinresponsetodifferentTLRagoNISTs.
TLR3,7,8and9belongtoathirdclassofTLRswhicharelocalizedintracellularwheretheydetectnucleicacidsderivedfromvirusesandbacteria.TLR7isrecognizedbysinglestrandedRNAinendosomes,whichisacommonfeatureofviralgenomeswhichareinternalizedbymacrophages.TLR7proteinsarelocalizedinendosomesand/orlysosomes.Recently,ithasbeendiscoveredthatTLR3,TLR7andTLR9traffickingrequiresUNC93B1,a12-membranespanningproteinthatresidesintheendoplasmaticreticulum.MiceorcellsthatlackUNC93B1function,aredefectiveinTLR3,TLR7andTLR9signaling.AssociationofUNC93B1withTLRsintheERfacilitatestheirtransporttotheendolysosome.
NKcellsareactivatedthroughTLR7/8andreportacentralroleformonocyte-derivedIL-12inthedifferentialIFN-producedbyNKcellsinresponsetodifferentTLRagoNISTs.
Specifications:
Catalognumber | HP9040 |
---|---|
Producttype | Polyclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Frozensections,Immunofluorescence,Immunoprecipitation,Paraffinsections,Westernblot |
Use | Forimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | SyntheticpeptideofhumanTLR7correspondingtoaminoacids706-728conjugatedtoKLH |
Isotype | RabbitIg |
Species | Human |
Alias | Toll-likereceptor7 |
References | 1.François,Setal;InhibitionofneutrophilapoptosisbyTLRagonistsinwholeblood:involvementofthephosphoinositide3-kinase/AktandNF-{kappa}Bsignalingpathways,leADIngtoincreasedlevelsofMcl-1,A1,andphosphorylatedbad.JImmunol2005,174:3633 2.Patole,Petal;ExpressionandregulationofToll-likereceptorsinlupus-likeimmunecomplexglomerulonephritisofMRL-Fas(lpr)mice.NephrolDialTransplant2006,21:3062 3.Pawar,Retal;Toll-likereceptor-7modulatesimmunecomplexglomerulonephritis.JAmSocNephrol2006,17:141 4.Brinkmann,Metal;TheinteractionbetweentheERmembraneproteinUNC93BandTLR3,7and9iscrucialforTLRsignaling.JCellBiol2007,177:265 5.Clark,Retal;HumansquamouscellcarcinomasevadetheimmuneresponsebydownregulationofvascularE-selectinandrecruitmentofregulatoryTcells.JExpMed2008,205:2221 |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Infectiousdiseases |