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商品描述
Description:IFN-gamma,Human,mAbF12
MonoclonalantibodybindsandneutralizesbothnaturalandrecombinanthumangammaInterferon.Crossreactivitywithothercytokineshasnotbeenfound.Theantibodydoesnotreactwithrodentinterferons.PossIBLeapplicationsincludethepurificationofhumangammaInterferonandinvitroneutralisation.Ingeneral,monoclonalantibodiestogammaInterferonareabletoinhibitSchwartzmanreactionsandinthemurinesystemappeartoprotectNZBmiceagainstspontaneousdevelopmentofautoimmunedisease.
Specifications:
Catalognumber | HM2003-03 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 300µg |
Formulation | LyophilizedproductinPBS,containing300µgantibody.Reconstitutethevialbyinjectionof1mldistilledorde-ionizedwater(Caution:vialisundervacuum). |
Application | Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation |
Use | Forimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.ForneutralizationofBIOLOGicalactivityinvitrodilutionshavetobemadeaccordingtotheamountofIFN-gammatobeinactivated.Oneneutralizingunitofanti-humangammainterferonisdefinedastheamountofantibodysufficientforneutralizingoneunithumangammainterferon(ref.:NIHstandardGg23-901-530). |
Isotype | MouseIgG1 |
Species | Human |
References | 1.Armstrong,JAetal;Semi-micro,dye-bindingassayforrabbitinterferon.JApplMicrobiol1971,21:723 2.Billiau,Aetal;Gamma-interferon:thematchthatlightsthefire?ImmunolToday1988,9:37 3.Jacob,COetal;Invivotreatmentof(NZBXNZW)F1lupus-likenephritiswithmonoclonalantibodytogammainterferon.JExpMed1987,166:798 4.Meidevander,PHetal;Monoclonalantibodiestohumanimmuneinterferonandtheiruseinasensitivesolid-phaseELISA.JImmunolMethods1985,79:293 |
StorageandstABIlity | Lyophilizedproductshouldbestoredat4 °C.Storestocksolutioninaliquotsat-20 °C.Repeatedfreezeandthawcycleswillcauselossofactivity.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Autoimmunity,Infectiousdiseases |