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商品描述
Description:Lactoferrin,Mouse,mAb1A10
Monoclonalantibodyclone1A10recognizesmouselactoferrin(LF).Theexpressionofsmallproteinsandpeptideswithmicrobialactivity,alsocalledantimicrobialpeptides(AMPs),isconsideredtobeaprimitivemechanismofimmunity.AMPsareproducedbyalmostallcelltypeswhicharecommonlyexposedtomicrobes.LactoferrinisamultifunctionalAMPandamajorelementofinnateimmunitybutalsoaffectsadaptiveimmunefunctions.LFisawellconservedmammaliannon-haemiron-binding80kDmonomericglycoproteinofthetransferrinfamily.Theproteinisfoundinmucosalsecretionlikesaliva,tears,urine,vaginalfluids,semen,urineandveryhighconcentrationsin(colostral)milk(1-7mg/ml).Itsprotectiveeffectsrangefromdirectantimicrobialactivitiesagainstalargepanelofmicroorganisms,includingbacteria,viruses,fungiandparasites,toanti-inflammatoryandanticanceractivities.ThemainfunctionsofLFresidedinspecificdomainsandhavepredominantlybefoundintheN-terminalside.Oneofthemainfunctionsisinhibitionofmicrobialgrowthbysequestrationofiron,whichisessentialforgrowth.TheN-terminalstructureofLFismainlyresponsIBLeforthisfunction.TheN-terminaldomaincontainsalsoaserine-protease-likeactivitywhichisinvolvedininactivationofhostcellinvasionbybacteria.Followinginfection,LFisreleasedfromsecondary-granulesofneutrophilsinbloodandinflamedtissueandfunctionsaspattern-recognitionreceptor.Therefore,LFplasmaconcentrationrepresentsapositiverelationtothetotalpoolofneutrophilsandtherateofneutrophilturnoverandcanbeusedasanindexforneutrophilactivation.Intheadaptiveimmuneresponse,LFpromotesthematurationofT-cellprecursorsintocompetenthelpercellsandbydifferentiationofimmatureB-cellsintoantigenpresentingcells.
Specifications:
Catalognumber | HM1132 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Immunoassays |
ApplicationNotes | FC:Antibody1A10stainsintracellular.Forintracellularstaining293cellswerepermeABIlizedandstainedwith2 µg/ml1A10. |
Use | ForImmunoAssay-dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting. |
Immunogen | Mouselactoferrinpeptide |
Isotype | MouseIgG2b |
Species | Mouse |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Autoimmunity,Infectiousdiseases |