品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
Description:OSCAR,Mouse,mAb5B8
Themonoclonalantibody5B8reactswithmouseosteoclast-associatedreceptor(OSCAR),whichisa265aminoacidtype1transmembraneproteinbelongingtotheleukocytereceptorcomplexproteinfamilythatplaycriticalrolesintheregulationofbothinnateandadaptiveimmuneresponses.Inmice,OSCARisaRANKL-inducIBLegenewhich-isexpressedduringthelaterstagesofpre-osteoclastmaturationandisshowntobeapotentFcRγ-associatedcostimulatoryreceptorinvitro.OSCARpromotesosteoclastogenesisinvivo,andOSCARbindingtoitscollagenligandledtosignalingthat-isinvolvedinfunctionaldifferentiationofleukocytes.InrecentstudieshumanOSCARhasbeenshowntoplaymultiplerolesintheimmunesystemincludingactivationandmaturationofimmunecells,preventionofapoptosisandenhancementofpro-inflammatorycircuits.Thelatterby-inducingintracellularcalciumreleaseresultinginsustainedIL-8andchemokineexpressionleADIngtochemotaxisofTh4effectorandregulatoryT-cells.Ina-murinemodelusingcalvariasboneexplants,thesynovialfluidofosteoarthritispatientsresultedinincreasedOSCARmRNAexpressionsuggestingthatOSCARmightcontributetointhedegenerativeprocess.Moreover,inarecentstudy-OSCARwasfoundtobe-inducedinmonocytesofRApatients,facilitatingtheirdifferentiationintoosteoclastsandboneresorption.Themonoclonalantibody,5B8,canbeusedforanalysisofmouseOSCARinflow-cytometryaswellasfunctionalstudiesforosteoclastogenesis.
Specifications:
Catalognumber | HM1121 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Functionalstudies |
Use | ForflowcytometryandImmunofluorescence,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser’sexperimentalsetting. |
Isotype | RatIgG2b |
Species | Mouse |
References | 1.Koga,Tetal;CostimulatorysignalsmediatedbytheITAMmotifcooperatewithRANKLforbonehomeostasis.Nature2004,428:758. 2.Hara,Hetal;Celltype-specificregulationofITAM-mediatedNF-{kappa}Bactivationbytheadaptors,CARMA1-andCARD9.J.Immunol2008,181:918. |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Autoimmunity,Tumorimmunology |