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商品描述
Description:FactorH,Mouse,mAb1A2
Monoclonalantibody1A2recognizesmousecomplementfactorH(CFH).CFHisthefirstregulatoryproteinofthealternativepathwayofthecomplementsystem.Therearethreepathwaysofcomplementactivation;classical,alternative,andlectinactivationpathway.ThesepathwaysconvergetoformC3/C5convertasesthatgenerateC3a,C3b,C5a,andC5b,eachwithsubstantialBIOLOGicactivity.Complementregulatorsarenecessarytopreventtheinjudiciousproductionofthesemediatorsandpotentialinjurytoself-tissue.TheplasmaproteinsCFH,C4-bindingproteinandthecellmembraneproteinscomplementreceptor1(CR1;CD35),decay-acceleratingfactor(CD55),andmembraneco-factorprotein(CD46)allaremembersoftheregulatorsofcomplementactivationfamily.TheseproteinshavenaturalaffinityforC3band/orC4b,whichconfersonthemtheABIlitytoacceleratetheintrinsicdecayofC3/C5convertasesand/oractasco-factorforthecleavageandinactivation(i)ofC3bandC4bbycomplementfactorI(CFI).GenetichumananalysesrevealsaclearassociationofCFHwithdifferenthumandiseases.Theseincludediseasesofthekidney,theatypicalformofHemolyticUremicSyndrome(aHUS)andmembranoproliferativeglomerulonephritis(MPGN).FurThermore,CFHisassociatedwithage-relatedmaculardegeneration(AMD),adiseaseoftheeye.
Specifications:
Catalognumber | HM1119 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Frozensections,Immunoassays,Westernblot |
Use | ForimmunohistologyandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | MousefactorH-humanIgGfusionprotein |
Isotype | MouseIgG1 |
Species | Mouse |
Crossreactivity | Rat-Yes |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Autoimmunity,Nephrology |