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商品描述
Description:CD59a,Mouse,mAb7A6
Themonoclonalantibody7A6(previouslyknownasmCD59.3)recognizesmouseCD59a,apotentinhibitorofthecomplementmembraneattackcomplex(MAC)action.CD59regulatestheformationandfunctionofthelyticC5b-9complexbybindingC8andpreventingtheunfoldingandmembraneinsertionofC9andbybindingC9andrestrictingitspolymerization.CD59isasmall(18-25kDa)molecule,linkedtothecellmembranethroughaglycosylphosphatidylinositol(GPI)anchorandcomprising77aminoacidswithasingleN-linkedcarbohydrategroupatAsn-18.AnaloguesofCD59canbefoundinallspecieswithsimilarstructuresandsizes.Incontrasttoallotherspecies,micehavetwogenesencodingaCD59aandaCD59bprotein.Thesetwomoleculesare63%identicalattheaminoacidlevelandshareallmajorstructuralfeatures.CD59aisbroadlydistributedonendothelia,erythrocytes,plateletsandonnumerousothercelltypesinorgans,adistributionpatternresemblingthatofCD59inotherspecies.ExpressionofCD59bisrestrictedtogermcellelementsinthetestisandmaturespermatozoa.BothCD59aandCD59binhibithumanandrodentcomplementwithsimilarefficiency.CD59maybeinvolvedinrheumatoidarthritis,motornerveinjuryintheGuillain-Barrésydromeandinotherdiseaseswheredefectiveinhibitionofcomplementactivationonselftissueisinvolved.FurThermore,CD59mayplayanimportantpartinabrogatingtheeffectsofcomplementattackinrenaldisease.Itspresenceandprotectiveeffecthavealreadybeendemonstratedonhumanrenalcells.
Specifications:
Catalognumber | HM1116 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µ/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunofluorescence,Westernblot |
Use | Forimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting. |
Immunogen | mCD59a-Fc |
Isotype | MouseIgG1 |
Species | Mouse |
Alias | Membraneattackcomplexinhibitionfactor,MACIF,MAC-inhibitoryprotein,Protectin,CD59 |
References | 1.Harris,Cetal;CharacterizationofthemouseanaloguesofCD59usingnovelmonoclonalantibodies:tissuedistributionandfunctionalcomparison.Immunology2003,109:117 2.Williams,Aetal;DeletionofthegeneencodingCD59ainmiceincreasesdiseaseseverityinamurinemodelofrheumatoidarthritis.ArthritisRheum2004,50:3035 3.Willison,Hetal;TheroleofcomplementandcomplementregulatorsinmediatingmotornerveterminalinjuryinmurinemodelsofGuillain–Barrésyndrome,JNeuroimmunol2008,201-202:172 4.Yang,Petal;ExpressionandModulationofRPECellMembraneComplementRegulatoryProteins.InvestOphthalmolVisSci2009,50:3473 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Autoimmunity,Infectiousdiseases |