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商品描述
Description:EphB1,B2,B3,Mouse,mAbEfB1-3
ThemonoclonalantibodyEfB1-3recognizesthemouseephrinreceptorsEphB1,EphB2andEphB3,118kDa,110kDaand110kDa,respectively.
Erythropoietin-producinghumanhepatocellularcarcinoma(Eph)receptorsandephrinsaremembraneproteins.Theyareclassifiedintotwosubclasses,namelyAandB,accordingtostructuralcharacteristicsandbindingspecificities.Ephreceptorsaretyrosinekinases,whichautophosphorylateuponbindingtotheircognateephrinligands.Ephreceptorsandephrinsarefrequentlyexpressedinreciprocalpatternsthatcorrelatewithcellularboundariesduringembryonicdevelopment.
AuniquefeatureofEph-ephrininteractionsisthattheycanfacilitatebi-directionalcommunicationbetweencells.Ephreceptorsandephrinligandsareinvolvedinvariousanimaldevelopmentprocesses,andimplicatedinsomecancers.Eph-ephrininteractionsmediateavarietyofcontact-dependentphenomenainboththedevelopingandmaturecentralnervoussystem.Theyareinvolvedinneuralcrestcellmigration,hindbrainsegmentation,morphogeneticmomentsduringgastrulation,brainguidanceintheinnerear,retinalganglioncellaxonguidanceandaxonbundlinginthehippocampus.
ThemonoclonalantibodyEfB1-3canalsobeusedtostainculturedspinalcordexplants.
Erythropoietin-producinghumanhepatocellularcarcinoma(Eph)receptorsandephrinsaremembraneproteins.Theyareclassifiedintotwosubclasses,namelyAandB,accordingtostructuralcharacteristicsandbindingspecificities.Ephreceptorsaretyrosinekinases,whichautophosphorylateuponbindingtotheircognateephrinligands.Ephreceptorsandephrinsarefrequentlyexpressedinreciprocalpatternsthatcorrelatewithcellularboundariesduringembryonicdevelopment.
AuniquefeatureofEph-ephrininteractionsisthattheycanfacilitatebi-directionalcommunicationbetweencells.Ephreceptorsandephrinligandsareinvolvedinvariousanimaldevelopmentprocesses,andimplicatedinsomecancers.Eph-ephrininteractionsmediateavarietyofcontact-dependentphenomenainboththedevelopingandmaturecentralnervoussystem.Theyareinvolvedinneuralcrestcellmigration,hindbrainsegmentation,morphogeneticmomentsduringgastrulation,brainguidanceintheinnerear,retinalganglioncellaxonguidanceandaxonbundlinginthehippocampus.
ThemonoclonalantibodyEfB1-3canalsobeusedtostainculturedspinalcordexplants.
Specifications:
Catalognumber | HM1113 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Frozensections,Immunofluorescence,Westernblot |
Use | ForimmunohistologyandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | RatEphB1-Fc |
Isotype | MouseIgG1 |
Species | Mouse |
Alias | Tyrosine-proteinkinasereceptorEPH-2,HEK6,ELK |
References | 1.Jevince,Aetal;DistributionofEphBreceptorsandephrin-B1inthedevelopingvertebratespinalcord.JCompNeurol2006,497:734 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Neurologicaldisorders,Tumorimmunology |