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商品描述
Description:VCAM-1,Mouse,mAb6C7.1
Themonoclonalantibody6C7.1recognizesmousevascularcelladhesionmolecule(VCAM-1)(~81kDa),amemberofasubclassoftheimmunoglobulinsuperfamily(IgSF).IgSFmembersareligandsforintegrins.Celladhesionmolecules(CAMs)haveimportantrolesintheimmuneresponse,immunesurveillanceandcell-cellrecognition,especiallyinleukocyte-endothelialcelladhesion.CAMsonthesurfaceofleukocytesandendothelialcellsareactivelyinvolvedintherecruitmentofspecificleukocytesubsetsintodifferenttissues.VCAM-1isexpressedoninflamedvascularendothelium,aswellasonmacrophage-likeanddendriticcelltypesinbothnormalandinflamedtissue.Celladhesionmolecules,likeVCAM-1,areupregulatedoncerebralvesselsduringinflammatoryconditionsofthecentralnervoussystemsuchasexperimentalautoimmuneencephalomyelitis(EAE),amodelsystemformultiplesclerosis.AdmiNISTrationofmonoclonalantibody6C7.1hasbeenshowntoinhibitordiminishclinicalorpathologicalsignsofEAE.VCAM-1isareceptorforencephalomyocarditisvirusonmurinevascularendothelialcells.ExpressionofVCAM-1onvascularendothelialcellsisinducedbyTNF-alpha,IL-1,IFN-gammaorendotoxin.VCAM-1isaligandfortheintegrinsalpha4beta1(VLA-4)andalpha4beta7(LPAM-1).Theseintegrinsareconstitutivelyexpressedbythymocytes,lymphocytesandmonocytes.VCAM-1/VLA-4interactionmayplayapathophysiologicalroleinimmuneresponsesandaswellasinleukocyteemigrationtositesofinflammation.
Specifications:
Catalognumber | HM1107 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Frozensections,Functionalstudies,Immunofluorescence,Immunoprecipitation |
Use | Forimmunofluorescenceandflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting. |
Immunogen | Mouseendothelialcells |
Isotype | RatIgG1 |
Species | Mouse |
Alias | CD106,INCAM-100,Vascularcelladhesionprotein1 |
References | 1.EngelhardtBetal;Thedevelopmentofexperimentalautoimmuneencephalomyelitisinthemouserequiresalpha4-Integrinbutnotalpha4beta7-Integrin.JClinInvest1998,102:2096 2.VajkoczyPetal;Alpha4-integrin-VCAM-1bindingmediatesGprotein-independentcaptureofencephalitogenicTcellblaststoCNSwhitemattermicrovessels.JClinInvest2001,108:557 3.KuligowskiMetal;Antimyeloperoxidaseantibodiesrapidlyinduce{alpha}4-integrin-dependentglomerularneutrophiladhesion.Blood2009,113:6485 4.KneillingMetal;DirectcrosstalkbetweenmastcellTNFandTNFR1-expressingendotheliamediateslocaltissueinflammation.Blood2009,114:1696 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Cardiologyandmetabolism,Tumorimmunology |