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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
Description:CD96,Mouse,mAb6A6,FITC
Themonoclonalantibody6A6recognizesmouseCD96.CD96orTcell-ActivatedIncreasedLateExpression(TACTILE)isan~67kDimmunoglobulin-likeproteinexpressedonnaturalkiller(NK)andTcells.CD96belongstotheIg-superfamily,consistingofthreeIg-likedomainsandanextendedserine/threonine/praline-richstalkintheectodomain.CD96isupregulateduponTcellactivationandisinvolvedinengagementofdiseasedcellsandcellmovementtowardsareasofinflammation.MouseCD96bindstoCD155andnectin-1.CD96/CD155-interactionispreservedbetweenmanandmousealthoughbothreceptorsareonlymoderatelyconservedinaminoacidsequence.Themonoclonalantibody6A6completelyinhibitsbindingofCD96tobothrecombinantmouseCD155andmousenectin-1.Also,TcelladhesiontoinsectcellsexpressingmCD155isblockedbythismonoclonalantibody,however,dependingontheTcellsubtype.Themonoclonalantibody6A6wasraisedafterimmunizationofratswithpurifiedrecombinantmCD96-hIgG1.
Specifications:
Catalognumber | HM1105F |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredFITCconjugatedantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide. |
Conjugate | FITC |
Application | Flowcytometry,Functionalstudies,Immunoassays,Westernblot |
Use | ForWesternblottingandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.ForfunctionalstudiesdilutionshavetobemadeaccordingtotheamountsofCD96tobeinactivated. |
Isotype | RatIgG2a |
Species | Mouse |
Crossreactivity | Mouse-Yes |
Alias | TACTILE |
References | 1.Seth,Setal;ThemurinepanTcellMarkerCD96isanadhesionreceptorforCD155andnectin-1.BiochemBiophysResCommun2007,364:959 2.Maier,Metal;TheadhesionreceptorCD155determinesthemagnitudeofhumoralimmuneresponsesagainstorallyingestedantigens.EurJImmunol2007,37:2214 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
Disease | Tumorimmunology |