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商品描述
Description:TNF-RI,Mouse,mAb55R-170
Themonoclonalantibody55R-170recognizestheextracellularpartofmouseTumorNecrosisFactorReceptorsuperfamilymember1A(TNF-RI),alsoknownasCD120aorp55.TNF-RIbelongstothelargeTNFreceptorfamily,amongwhichTNF-RII(TNF-Rp75-80),lymphotoxin-betareceptor(LTbetaR)andtheHerpesvirusentrymediator(HVEM).LigandsforthesereceptorsbelongtotheTumorNecrosisFactor(TNF)superfamilyofcytokines,whichactivatesignalingpathwaysforcellsurvival,death,anddifferentiationthatorchestratethedevelopment,organizationandhomeostasisoflymphoid,mammary,neuronalandectodermaltissues.TNF-RIcontainsacharacteristicstructuralcassettetermeddeathdomaininitssequencethatisconservedwithinadistinctsubsetofotherTNF-Rfamilymembers,suchasCD95,DR3,DR4,andDR5.Thisdeathdomain,wascharacterizedasbeingessentialforinductionofapoptosisinvitroandhasbeenstructurallyconservedwithintheseTNF-Rsuperfamilymembers.DeletionofthedeathdomainoftheTNF-RIresultsinanon-functionalreceptor,indicatingthatthedeathdomainisrequiredforthesignaltransductionofthephysiologicalfunctionsofTNF-RIinvivo.TNF-RIisa55kDtypeItransmembraneproteinandisexpressedonavarietyofcelltypesatlowlevels.ItisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TNF-RIispresentassolubleforminbodyfluids(forinstanceplasmaandCSF).ThisextracellularTNF-RIisgeneratedbytwomechanisms,namelyproteolyticcleavageofTNF-RIectodomainsandreleaseoffull-lengthTNF-RIinthemembranesofexosome-likevesicles.TNF-RIandTNF-RIIbothinteractwiththehomomericformsofLTbetaorTNF.However,TNF-RIfunctionsasthehighaffinityreceptorforsolubleTNF(sTNF).TNF-RIhasbeenshowntobeinvolvedinawidevarietyofinflammatorydiseases,amongwhichneurodegenerativediseases(Parkinson"sandAlzheimer"sdisease),multiplesclerosis,asthma,atherosclerosis,rheumatology.Themonoclonalantibody55R-170alsorecognizesthesolublereceptor..
Specifications:
| Catalognumber | HM1097 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
| Application | Flowcytometry,Functionalstudies,Immunoassays,Immunoprecipitation |
| Use | Forflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting. |
| Immunogen | PurifiedsolubleextracellulardomainofmouseTNF-RI |
| Isotype | ArmenianhamsterIgG |
| Species | Mouse |
| Alias | TNFRtypeI,CD120a,TNF-RI,TNF-R55,TNFRp55,p55-R,TNFreceptoralphachain |
| References | 1.Sheehan,Ketal;Monoclonalantibodiesspecificformurinep55andp75tumornecrosisfactorreceptors:identificationofanovelinvivoroleforp75.JExpMed1995,181:607 2.Pinckard,Jetal;Ligand-inducedformationofp55andp75tumornecrosisfactorreceptorheterocomplexesonintactcells.JBiolChem1997,272:10784 3.Ji,Hetal;Criticalrolesforinterleuking1andtumornecrosisfactoralphainantibody-inducedarthritis.JExpMed2002,196:77 4.Lee,Setal;InhibitionofTCR-inducedCD8TcelldeathbyIL-12:regulationofFasligandandcellularFLIPexpressionandcaspaseactivationbyIL-12.JImmunol2003,170:2456 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
