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商品描述
Description:MGL,Mouse,mAbER-MP23
ThemonoclonalantibodyER-MP23specificallyreactswiththemacrophagegalactose-specificlectin(MGL),a38kDasinglechainsurfaceglycoprotein.MGLisfoundonmurinematuremacrophagesintheconnectivetissueneighboringepitheliaofe.g.salivaryglands,capsuleoflymphnodes,thymusandvariousotherorgans.MGLispresentonthesurfaceofconnectivetissuemacrophagesandtheirprecursorcellsinbonemarrow.Also,MGLisexpressedinmacrophagecelllines(e.g.J774-1.6,RAW309Cr.1andWR19M.1).ExpressionlevelsofMGLareincreasedinmaturemacrophages.TheantigeniscoexpressedwiththeantigenrecognizedbymonoclonalantibodyBM8(HM1066).
ThemonoclonalantibodyER-MP23hasbeenraisedafterimmunizationofratswithmousemacrophagecelllines.BlockingstudiesdemonstratedthatthemonoclonalantibodyER-MP23isabletoblockmouseMGL.
ThemonoclonalantibodyER-MP23hasbeenraisedafterimmunizationofratswithmousemacrophagecelllines.BlockingstudiesdemonstratedthatthemonoclonalantibodyER-MP23isabletoblockmouseMGL.
Specifications:
Catalognumber | HM1081 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100μg/ml)0.2μmproteinGpurifiedantibodysolutioninPBS,containing0.1%bovineserumalbumin.Theendotoxinconcentrationis<24EU/mg,determinedwithHIT302LALAssay. |
Application | Flowcytometry,Frozensections,Functionalstudies,Paraffinsections |
ApplicationNotes | FS:Forblockingstudiesinvitro,dilutionshavetobemadeaccordingtotheamountsofMGLtobeinactivated.Theantigenisglutaraldehyde(0.05%)resistant. |
Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | Mousemacrophagecelllines |
Isotype | RatIgG2a |
Species | Mouse |
Alias | Macrophagegalactose-specificlectin,CD301,dendriticcell-asialoglycoproteinreceptor,DC-ASGPR |
References | 1.Jansen,Aetal;Immunohistochemicalcharacterizationofmonocytes-macrophagesanddendriticcellsinvolvedintheinitiationoftheinsulitsandbeta-celldestructioninNODmice.Diabetes1994,43:667 2.Rosmalen,Jetal;IsletabnormalitiesassociatedwithanearlyinfluxofdendriticcellsandmacrophagesinNODandNODscidmice.LabInvest2000,80:769 3.AbADIe,Vetal;NeutrophilsrapidlymigratevialymphaticsafterMycobacteriumbovisBCGintradermalvaccinationandshuttlelivebacillitothedraininglymphnodes.Blood2005,106:1843 |
StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Infectiousdiseases |