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商品描述
Description:C5aR,Mouse,mAb10/92
Themonoclonalantibody10/92recognizesthemousereceptorC5a(C5aR,CD88).ThemouseanaphylatoxinC5aisa74-residuglycopolypeptidewhichisgeneratedbyproteolyticcleavageofthecomplementfactorC5inthecourseofcomplementactivation.AvarietyofBIOLOGicaleffectsevokedbyC5acouldbedemonstrated,renderingthismoleculeanimportantmediatorofinflammation,withgranulocytesandmacrophagesasthemaintargetcells.AllcellularresponsestoC5aarespecificallymediatedbyinteractionswiththemembraneboundC5areceptor,aseventransmembraneGTP-binding-protein-coupledreceptorthatbelongstotherhodopsinsupergenefamily.The45kDaC5areceptorisexpressedbyneutrophils,monocytes/macrophages,dendriticcells,astrocytesandmicroglia.Incontrast,C5areceptorisnotdetectableonrestingorstimulatedmurineTandBlymphocytes.Themonoclonalantibody10/92doesnotinhibitthebindingofC5atoitsreceptor.
Specifications:
Catalognumber | HM1077 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Frozensections,Westernblot |
Use | Forimmunohistology,Western-blotting-andflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | RBL-2H3transfectantsexpressingmurineC5aR |
Isotype | RatIgG2a |
Species | Mouse |
Alias | C5aR1,CD88 |
References | Soruri,Aetal;CharacterizationofC5aRexpressiononmurinemyeloidandlymphoidcellsbytheuseofanovelmonoclonalantibody.ImmunolLett2003,88:47 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Infectiousdiseases,Nephrology |