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商品描述
Description:CD36,Mouse,mAbCRFD2712
MonoclonalantibodyCRFD-2712(alsoknownasJC63.1or63)reactswithmouseCD36(85-kDa),acellsurfaceclassBscavengerreceptor.Recently,CD36hasbeenidentifiedasaproteinthatisrequiredforTLR2recognitionofdi-acylatedbacteriallipopeptidesandlipoteichoicacid.CD36isaheavilyN-glycosylatedtransmembraneproteinwithtwoshortintracellulardomainsandalargeextracellulardomain.CD36expressionisprimarilycontrolledbythetranscriptionheterodimerPPARg-RXR(peroxisomeproliferator-activatedreceptor-g-retinoid-X-receptor).CD36ispreferentiallyfoundwithinlipidrafts,whichfacilitatesitsassociationwithreceptors,signallingandadaptormolecules.CD36isexpressedonmonocytes,macrophages,endothelialcells,hepatocytes,erythrocytes,ADIpocytes,cardiomyocytesandredskeletalmuscle.Importantlyitisexpressedbysteriodogeniccellsintheadrenalgland,testisandovary.CD36hasbeenimplicatedinmanyBIOLOGicalprocessesincludingangiogenesis,phagocytosis,inflammation,andlipidandglucosemetabolism.CD36isassociatedwithSrc-familykinasesandwiththeintegrinsalpha3beta1andalpha6beta1.Itisareceptorandtransporterofoxidizedlipidsandlongchainfattyacids.CD36hasbeenshowntofunctionasphagocyticreceptorforapoptoticcells.Severalinvivomodelssupporttheroleofthethrombospondin/CD36systeminangiogenesisandtumorgrowth.AnimportantroleforCD36hasbeenfoundinMalariaasmajorreceptorforP.falciparum-infectedredbloodcells.ManydifferentligandshavebeenreportedtointeractwithCD36,suggestingthatCD36couldrecognizeastructure-baseddomainratherthanspecificcontactresidues.MonoclonalantibodyCRFD-2712blocksCD36binding.Itisnotknownwhethertheantibodyisactivatingorneutralizing.TheantibodycrossreactswithratCD36.
Specifications:
Catalognumber | HM1074 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 200µg |
Formulation | 2ml(100µg/ml)culturemediumwithlowendotoxinlevel. |
Application | Flowcytometry,Functionalstudies,Immunofluorescence,Immunoprecipitation,Westernblot |
Use | ForflowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:25.ForfunctionalstudiesdilutionshavetobemadeaccordingtotheamountsofCD36bindingtobeblocked. |
Isotype | MouseIgA |
Species | Mouse |
References | 1.Finnemann,Setal;DifferentialrolesofCD36andalpha-v-beta5integrininphotoreceptorphagocytosisbytheretinalpigmentepithelium.JExpMed2001,9:1289 2.Kunjathoor,Vetal;ScavengerreceptorsclassAI/IIandCD36aretheprincipalreceptorsresponsIBLefortheuptakeofmodifiedlowdensitylipoproteinleadingtolipidloadinginmacrophages.JBiolChem2002,277:49982 3.Corcoran,Letal;DifferentialregulationofCD36expressioninantigen-presentingcells:Oct-2dependenceinBlymphocytesbutnotdendriticcellsormacrophages.IntImmunol2002,14:1099 4.Smith,Tetal;CD36-mediatednonopsonicphagocytosisoferythrocytesinfectedwithstageIandIIAgametocytesofplasmodiumfalciparum.InfectImmun2003,71:393 5.Gimeno,Retal;Characterizationofaheart-specificfattyacidtransportprotein.JBiolChem2003,278:16039 6.Bastie,Cetal;FoxO1stimulatesfattyaciduptakeandoxidationinmusclecellsthroughCD36-dependentandindependentmechanisms.JBiolChem2005,280:14222 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Cardiologyandmetabolism,Infectiousdiseases |