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蚂蚁淘在线 / 品牌中心 / Hycult Biotech / Hycult Biotech/SAA-1, Human, mAb Reu86.1, immuno assay antibody/HM2100-IA/0.5 mg
商品描述
Description:SAA-1,Human,mAbReu86.1,immunoassayantibody
TheserumamyloidA(SAA)familycomprisesanumberofdifferentiallyexpressedapolipoproteins,acute-phaseSAA1andSAA2,theformerbeingthemajorcomponentinplasma,andconstitutiveSAAs(C-SAAs).AlthoughtheliveristheprimarysiteofsynthesisofbothSAAtypesextrahepaticproductionhasbeenreported.Theinvivoconcentrationsincreasebyasmuchas1000-foldduringinflammation.Severalstudieshavestresseditsimportanceinthediagnosisandmonitoringofvariousdiseases.PathologicalSAAvaluesareoftendetectedinassociationwithnormalCRPconcentrations;SAArisesearlierandmoresharplythanCRP.
Recently,abroaderviewofSAAexpressionandfunctionhasbeenemerging.ExpressionstudiesshowproductionofSAAproteinsinhistologicallynormal,atherosclerotic,Alzheimer,inflammatory,andtumortissues.SAAhasbeenfoundtohavebindingsitesforhighdensitylipoproteins,calcium,laminin,andheparin/heparan-sulfate.Alsoadhesionmotifswereidentifiedandnewfunctions,affectingcelladhesion,migration,proliferationandaggregationdiscovered.ThesefindingsemphasizetheimportanceofSAAinvariousphysiologicalandpathologicalprocesses,includinginflammation,atherosclerosis,thrombosis,AA-amyloidosis,rheumatoidarthritis,andneoplasia.SAAhasalsoanumberofimmunomodulatoryroles,itcaninducechemotaxisandadhesionmoleculeexpression,hascytokine-likepropertiesandcanpromotetheupregulationofmetalloproteinases.Itenhancesthebindingofhigh-densitylipoproteintomacrophagesandthushelpsinthedeliveryoflipidstositesofinjuryforuseintissuerepair.Itisthusthoughttobeanintegralpartofthediseaseprocesses.Inaddition,recentexperimentssuggestthatSAAmayplaya"housekeeping"roleinnormalhumantissues.ElevatedlevelsofSAAovertimepredisposetosecondaryamyloidosis,extracellularaccumulationofamyloidfibrils,derivedfromacirculatingprecursor,invarioustissueandorgans.Themostcommonformofamyloidosisoccurssecondarytochronicinflammatorydisease,particularlyrheumatoidarthritis.TheantibodyisraisedagainsthumanSAAandHelixPomatiaHaemocyanine.ItreactsspecificallywithSAA-1,themajorisoformofSAAinplasma.
Recently,abroaderviewofSAAexpressionandfunctionhasbeenemerging.ExpressionstudiesshowproductionofSAAproteinsinhistologicallynormal,atherosclerotic,Alzheimer,inflammatory,andtumortissues.SAAhasbeenfoundtohavebindingsitesforhighdensitylipoproteins,calcium,laminin,andheparin/heparan-sulfate.Alsoadhesionmotifswereidentifiedandnewfunctions,affectingcelladhesion,migration,proliferationandaggregationdiscovered.ThesefindingsemphasizetheimportanceofSAAinvariousphysiologicalandpathologicalprocesses,includinginflammation,atherosclerosis,thrombosis,AA-amyloidosis,rheumatoidarthritis,andneoplasia.SAAhasalsoanumberofimmunomodulatoryroles,itcaninducechemotaxisandadhesionmoleculeexpression,hascytokine-likepropertiesandcanpromotetheupregulationofmetalloproteinases.Itenhancesthebindingofhigh-densitylipoproteintomacrophagesandthushelpsinthedeliveryoflipidstositesofinjuryforuseintissuerepair.Itisthusthoughttobeanintegralpartofthediseaseprocesses.Inaddition,recentexperimentssuggestthatSAAmayplaya"housekeeping"roleinnormalhumantissues.ElevatedlevelsofSAAovertimepredisposetosecondaryamyloidosis,extracellularaccumulationofamyloidfibrils,derivedfromacirculatingprecursor,invarioustissueandorgans.Themostcommonformofamyloidosisoccurssecondarytochronicinflammatorydisease,particularlyrheumatoidarthritis.TheantibodyisraisedagainsthumanSAAandHelixPomatiaHaemocyanine.ItreactsspecificallywithSAA-1,themajorisoformofSAAinplasma.
Specifications:
Catalognumber | HM2100-IA |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 0.5mg |
Formulation | 0.5mgof0.2μmproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel). |
Application | Frozensections,Immunoassays,Paraffinsections,Westernblot |
ApplicationNotes | W:AreducedsampletreatmentandSDS-Pagewasused.Thebandsizeis12kDa. IA:HM2100canbeusedasadetectionantibody. |
Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | Apo-SAAcoupledtoHelixPomatiaHaemocyanine(Ref.1) |
Isotype | MouseIgG1 |
Species | Human |
Crossreactivity | Mouse-Yes |
Alias | SerumamyloidA-1protein Genename:SAA1 |
References | 1.Hazenberg,Betal;MonoclonalantibodybasedELISAforhumanSAA.AmyloidandAmyloidosis,eds.LBNatvigetal,KluwerAcadPubl1990:898 2.Wilkins,Jetal;RapidautomatedenzymeimmunoassaysofSerumAmyloidA.ClinChem1994,40:12843.Hazenberg,Betal;AquantitativemethodfordetectingdepositsofamyloidAproteininaspiratedfattissueofpatientswitharthritis.AnnRheumDis1999,58:96 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Autoimmunity |