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Hycult Biotech/SAA-1, Human, mAb Reu86.1, immuno assay antibody/HM2100-IA/0.5 mg

价格
¥23664.00
货号:HM2100-IA
浏览量:62
品牌:Hycult Biotech
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商品描述

Description:SAA-1,Human,mAbReu86.1,immunoassayantibody

TheserumamyloidA(SAA)familycomprisesanumberofdifferentiallyexpressedapolipoproteins,acute-phaseSAA1andSAA2,theformerbeingthemajorcomponentinplasma,andconstitutiveSAAs(C-SAAs).AlthoughtheliveristheprimarysiteofsynthesisofbothSAAtypesextrahepaticproductionhasbeenreported.Theinvivoconcentrationsincreasebyasmuchas1000-foldduringinflammation.Severalstudieshavestresseditsimportanceinthediagnosisandmonitoringofvariousdiseases.PathologicalSAAvaluesareoftendetectedinassociationwithnormalCRPconcentrations;SAArisesearlierandmoresharplythanCRP.
Recently,abroaderviewofSAAexpressionandfunctionhasbeenemerging.ExpressionstudiesshowproductionofSAAproteinsinhistologicallynormal,atherosclerotic,Alzheimer,inflammatory,andtumortissues.SAAhasbeenfoundtohavebindingsitesforhighdensitylipoproteins,calcium,laminin,andheparin/heparan-sulfate.Alsoadhesionmotifswereidentifiedandnewfunctions,affectingcelladhesion,migration,proliferationandaggregationdiscovered.ThesefindingsemphasizetheimportanceofSAAinvariousphysiologicalandpathologicalprocesses,includinginflammation,atherosclerosis,thrombosis,AA-amyloidosis,rheumatoidarthritis,andneoplasia.SAAhasalsoanumberofimmunomodulatoryroles,itcaninducechemotaxisandadhesionmoleculeexpression,hascytokine-likepropertiesandcanpromotetheupregulationofmetalloproteinases.Itenhancesthebindingofhigh-densitylipoproteintomacrophagesandthushelpsinthedeliveryoflipidstositesofinjuryforuseintissuerepair.Itisthusthoughttobeanintegralpartofthediseaseprocesses.Inaddition,recentexperimentssuggestthatSAAmayplaya"housekeeping"roleinnormalhumantissues.ElevatedlevelsofSAAovertimepredisposetosecondaryamyloidosis,extracellularaccumulationofamyloidfibrils,derivedfromacirculatingprecursor,invarioustissueandorgans.Themostcommonformofamyloidosisoccurssecondarytochronicinflammatorydisease,particularlyrheumatoidarthritis.TheantibodyisraisedagainsthumanSAAandHelixPomatiaHaemocyanine.ItreactsspecificallywithSAA-1,themajorisoformofSAAinplasma.

Specifications:

CatalognumberHM2100-IA
ProducttypeMonoclonalantibodies
Quantity0.5mg
Formulation0.5mgof0.2μmproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).
ApplicationFrozensections,Immunoassays,Paraffinsections,Westernblot
ApplicationNotesW:AreducedsampletreatmentandSDS-Pagewasused.Thebandsizeis12kDa.
IA:HM2100canbeusedasadetectionantibody.
UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
ImmunogenApo-SAAcoupledtoHelixPomatiaHaemocyanine(Ref.1)
IsotypeMouseIgG1
SpeciesHuman
CrossreactivityMouse-Yes
AliasSerumamyloidA-1protein
Genename:SAA1
References1.Hazenberg,Betal;MonoclonalantibodybasedELISAforhumanSAA.AmyloidandAmyloidosis,eds.LBNatvigetal,KluwerAcadPubl1990:898
2.Wilkins,Jetal;RapidautomatedenzymeimmunoassaysofSerumAmyloidA.ClinChem1994,40:12843.Hazenberg,Betal;AquantitativemethodfordetectingdepositsofamyloidAproteininaspiratedfattissueofpatientswitharthritis.AnnRheumDis1999,58:96
StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.
DiseaseAutoimmunity
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