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蚂蚁淘在线 / 品牌中心 / Hycult Biotech / Hycult Biotech/TNF-RI, Human, mAb MR1-2, functional study antibody, low endotoxin/HM2005-FS/0.5 mg
商品描述
Description:TNF-RI,Human,mAbMR1-2,functionalstudyantibody,lowendotoxin
TheantibodyMR1-2reactswiththeextra-cellularpartoftheTNF-RI.Italsoreactswiththesolublereceptor.TNF-RIispresentonmostcelltypesandisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha:InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TheantibodycrossreactswithrhesusandcynomolgusnaturalTNF-RI.
Specifications:
Catalognumber | HM2005-FS |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 0.5mg |
Formulation | 0.5mg(100μg/ml)0.2μmfilteredproteinGpurifiedantibodysolutioninPBSwithaconcentrationofatleast0.5mg/ml(exactconcentrationisindicatedonthelabel).Theendotoxinconcentrationis<24EU/mg,determinedwithHIT302LALAssay. |
Application | Flowcytometry,Functionalstudies |
Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Immunogen | ExtracellularpartofTNF-R55 |
Isotype | MouseIgG1 |
Species | Human |
Crossreactivity | Cynomolgusmonkey-Yes,Rhesusmonkey-Yes |
Alias | Tumornecrosisfactorreceptorsuperfamilymember1A,TumornecrosisfactorreceptortypeI Genename:TNFRSF1A |
PositiveControl | HumanlymphnodesorPHAactivatedTcells |
References | 1.Leeuwenberg,JFMetal;SlowreleaseofsolubleTNF-Receptorsbymonocytesinvitro.JImmunol1994,152:4036 2.Leeuwenberg,JFMetal;LipopolysaccharideLPS-mediatedsolubleTNF-ReceptorreleaseandTNF-Receptorexpressionbymonocytes;roleofCD14,LPSbindingproteinandbactericidal/permeABIlity-increasingprotein.JImmnol1994,152:5070 3.Marchetti,Letal;Tumornecrosisfactor(TNF)-mediatedneuroprotectionagainstglutamate-inducedexcitotoxicityisenhancedbyN-methyl-D-aspartatereceptoractivation.EssentialroleofaTNFreceptor2-mediatedphosphatidylinositol3-kinase-dependentNF-kappaBpathway.JBiolChem2004,279:32869 |
Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HbtisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
Disease | Autoimmunity,Gastroenterology |