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蚂蚁淘在线 / 品牌中心 / Hycult Biotech / Hycult Biotech/Collagen II, Mouse, mAb M2139, functional study antibody, low endotoxin/HM1063-FS/0.5 mg
商品描述
Description:CollagenII,Mouse,mAbM2139,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyM2139reactswiththeJ1epitope(triplehelicalposition551-564)ofcollagentypeII.Collagenisastructuralproteininbone,cartillageandconnectivetissue.CollagentypeII(CII)isthemajorcollagenofthenucleuspulposa(acomponentofspine),cartilageandvitreous(acomponentoftheeye).Themostcommonlyusedanimalmodelforrheumatoidarthritis(RA)isthecollagen-inducedarthritis(CIA).TransferofcollagentypeIIspecificmonoclonalantibodiesinducesanacuteformofarthritis(collagentypeIIantibodyinducedarthritis,CAIA).ThemonocolonalantibodyM2139hasbeenshowntoinduceCAIAinnaïvemiceafterinjectionoflipopolysacharide(LPS).However,incombinationwiththemonoclonalantibodyCIIC1,bindingtotheC1epitopeofCII,thepairofmonoclonalantibodiesinducearthritisindifferentstrainsofmicewithoutanyotherstimulants.Thepresenceofsecondarystimulus,LPS,increasesthediseaseincidenceandseverity.ThemonoclonalantibodyM2139iscrossreactivewithrat,bovine,chickenandhumanCII.
Specifications:
| Catalognumber | HM1063-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg-(100µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel) |
| Application | Functionalstudies,Immunoassays,Paraffinsections |
| ApplicationNotes | ThemonoclonalantibodyM2139canbeusedforfunctionalstudiesandforimmunohistologyonparaffinembeddedsections.FurThermorethemonoclonalantibodyM2139isusefulinimmunoassaysascoatinganddetection. FS:M2139supressestheself-assemblyofCIIintofibrils(ref.2) |
| Use | Forimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:25. |
| Isotype | MouseIgG2b |
| Species | Mouse |
| Crossreactivity | Bovine-Yes,Chicken-Yes,Human-Yes,Rat-Yes |
| References | 1.Nandakumar,Ketal;CollagenTypeII-specificmonoclonalantibody-inducedarthritisinmice.Descriptionofthediseaseandtheinfluenceofage,sexandgenes.AmJPathol2003,163:1827 2.Nandakumar,Ketal;CollagentypeII(CII)-specificantibodiesinducearthritisintheabsenceofTorBcellsbutthearthritisprogressionisenhancedbyCII-reactiveTcells.ArthritisResTher2004,6:R544 3.Cook,Aetal;Urokinase-typeplasminogenactivatorandarthritisprogression:roleinsystemicdiseasewithimmunecomplexinvolvement.ArthritisResearch&Therapy2010,12:R37 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity |
