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蚂蚁淘在线 / 品牌中心 / Hycult Biotech / Hycult Biotech/PTX3, Human, mAb MNB1, functional study antibody, low endotoxin/HM2241-FS/0.5 mg
商品描述
Description:PTX3,Human,mAbMNB1,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyMNB1(previouslyknownasclone16B5)recognizeshumanpentraxin3(PTX3),belongingtothelongpentraxinfamily.PTX3isanacute-phaseglycoproteinof~45kDawithglycosylationaccountingforabout10%ofitsmolecularweight.PTX3hasacomplexoligomericstructurewithprotomerslinkedtoeachotherbydisulfidebonds.PTX3expressionistriggeredbyinflammatorycytokines,resultinginhigherlevelsofcirculatingPTX3.SeveralcelltypeshavebeenreportedtoproducePTX3,namelymacrophages,endothelialcells,neutrophilsandsynoviocytes.PTX3isinvolvedinhostdefenseagainstpathogeninfection,intheregulationofthescavengeractivityofmacrophagesanddendriticcells,andinmodulationofcomplementactivitybybindingtoC1q.FurThermore,PTX3hasbeenimplicatedinmatrixdepositionofcumuluscells.Moreover,PTX3interactswithotherBIOLOGicallyactivemolecules,causingtheirfunctionalblockade.Thishasbeendemonstratedforfibroblastgrowthfactor-2(FGF-2),forwhichPTX3actsasaninhibitor,leADIngtoinhibitionofangiogenesis.PTX3,likeotherpentraxinsC-reactiveprotein(CRP)andserumamyloidPcomponent(SAP),bindsapoptoticcellsanddebris.PTX3isusefulasanearlyindicatorofmyocyteirreversIBLeinjuryinischemiccardiomyopathy.PTX3isnotonlyinvolvedininflammatoryvesseldiseasesrelatedtoatherosclerosis,butalsoinpre-eclampsiaandsystemicsmallvesselANCA-associatedvasulitis,inwhichneutrophilsarekeyplayers.Therelationshipbetweentissuedamageandpentraxingenerationisstringentinacuteinjuries.PTX3tunesself-non-selfdiscriminationandtissuerepairduetotherecognitionofdiverseligandsbyPTX3andthroughregulationofeffectorpathways.
Specifications:
| Catalognumber | HM2241-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel). |
| Application | Flowcytometry,Functionalstudies,Immunoassays,Westernblot |
| ApplicationNotes | IA:theantibodycanbeusedasdetectionantibody. W:Reducedsampletreatment.Theexpectedbandsizesareapproximately42and90kDa. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | HumanrecombinantPTX3 |
| Isotype | RatIgG2b |
| Species | Human |
| Alias | PTX3,Pentraxin-relatedproteinPTX3,Tumornecrosisfactor-induciblegene14protein,TSG-14 Genename:PTX3,TNFAIP5,TSG14 |
| References | 1.Bottazzi,Betal;MultimerFormationandLigandRecognitionbytheLongPentraxinPTX3.JBC1997,272:32817 2.Camozzi,Metal;IdentificationofanAntiangiogenicFGF2-bindingSiteintheNTerminusoftheSolublePatternRecognitionReceptorPTX3*.JBC2006,281:22605 3.Jaillon,Setal;ThehumoralpatternrecognitionreceptorPTX3isstoredinneutrophilgranulesandlocalizesinextracellulartraps.JExpMed2007,204:793 4.Jaillon,Setal.EndogenousPTX3translocatesatthemembraneoflateapoptotichumanneutrophilsandisinvolvedintheirengulfmentbymacrophages.CellDeathDiff2009,16:465-474 5.Hamon,Yetal,ProteolyticcleavageofthelongpentraxinPTX3intheairwaysofcysticfibrosispatients.InnImm2013,19:611 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Infectiousdiseases |
