Description:

Transforminggrowthfactor-beta1(TGF-beta1)isamultifunctionalpeptidethatcontrolsproliferation,differentiation,andotherfunctionsinmanycelltypes.ManycellssynthesizeTGF-betaandessentiallyallofthemhavespecificreceptorsforthispeptide.TGF-betaregulatestheactionsofmanyotherpeptidegrowthfactorsanddeterminesapositiveornegativedirectionoftheireffects.TGFbeta1isknownforitspotentanddiverseBIOLOGicaleffects,includingimmuneregulation,andcellgrowthanddifferentiation.TGFbeta1isalsoanimportantmediatorofboneremodeling.TGFbeta1,apotentkeratinocytegrowthinhibitor,hasbeenshowntobeoverexpressedinkeratinocytesincertaininflammatoryskindiseasesandhasbeenthoughttocounteracttheeffectsofothergrowthfactorsatthesiteofinflammation.TGF-beta1,amultifunctionalcytokinewithfibrogenicproperties,hasbeenimplicatedinthepathogenesisofthevascularandtargetorgancomplicationsofhypertension.TGF-beta1mayalsoregulatebloodpressureviastimulationofendothelin-1and/orreninsecretion.TGFbeta1issecretedasalatentform,whichconsistsofitsmatureformandalatency-associatedpeptide(beta1-LAP)ineitherthepresenceortheabsenceofadditionallatentTGF-beta1-bindingprotein.ThestandardproductusedinthiskitisrecombinantTGFbeta1withthemolecularmassof25KDa.

AdditionalInformation:

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Name	RatTGFbeta1ELISAKit
RelatedProductNames	Camurati-Engelmanndisease|CED|DPD1|LAP|Latency-associatedpeptide|TGFbeta1protein|TGF-beta-1|TGFB|tgfb1|TGFB1_HUMAN|TGFbeta|Transforminggrowthfactorbeta1
ShortDescription	SandwichELISAkitofQuantitativeDetectionforRatTGFbeta1
Immunogen	CHO,A279-S390
StandardRange	15.6pg/ml-1000pg/ml.Testhasasensitivityof<1="">
SampleType	ThiskitisusedforquantitativedetectionofactivatedratTGFbeta1incellculturesupernates,serum,plasma(EDTA)andurine.
Specimen/Volumes	RefertoManual
SwissProtNumber	P17246
Concentration	LotSpecific
Applications	ELISA
GINumber	59086
StABIlity	Fourmonthsat4Candeightmonthsat-20C.
Reactivity	ReactivetoRat.Thereiscross-reactivateswithTGFbeta2,TGFbeta3,TGFbeta5<>
KitSize	1x96wellplate
Storage	Storeat4°Cfor6months,at-20°Cfor12months.Avoidmultiplefreeze-thawcycles(Shippedwithwetice.)
IntendedUse	ResearchUseOnly