Description:

Description	TheCMVIgMELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgMclassantibodiestoCytomegalovirusinhumanserumorplasma.Cytomegalovirus(CMV)isamemberoftheherpesgroupofviruses.MostadultsandchildrenwhocatchCMVhavenosymptomsandarenotharmedbythevirus.CMVinfectionisofclinicalsignificanceprimarilyinpregnantwomen,newborninfantswithpossIBLecongenitalinfection,immunosuppressedtransplantpatientsandindividualswithAIDS.CMVissoprevalentasover60%ofpeoplecatchtheinfectionatsometimeintheirlives.SignificantincreasesinCMVIgGantibodybyELISAsuggestrecentinfectionorreactivationofalatentCMVinfection.CMVIgMantibodycanbedetectedbyELISAinbothprimaryCMVinfections(93-100%)andinreactivatedinfection(40%).AnIgMresponsemaybereducedorabsentinimmunocompromisedpatientswithactiveinfection.IntransplantpatientstheCMVinfectioncanbeassociatedwithhighermorbidityandmortality.
Species	Human
SampleType	SerumorPlasma

AdditionalInformation:

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Name	CMVIgMELISA
ShortDescription	TheCMVIgMELISAtestsystemisanenzymelinkedimmunosorbentassay(ELISA)forthedetectionofIgMclassantibodiestoCytomegalovirusinhumanserumorplasma.Cytomegalovirus(CMV)isamemberoftheherpesgroupofviruses.MostadultsandchildrenwhocatchCMVhavenosymptomsandarenotharmedbythevirus.CMVinfectionisofclinicalsignificanceprimarilyinpregnantwomen,newborninfantswithpossiblecongenitalinfection,immunosuppressedtransplantpatientsandindividualswithAIDS.CMVissoprevalentasover60%ofpeoplecatchtheinfectionatsometimeintheirlives.SignificantincreasesinCMVIgGantibodybyELISAsuggestrecentinfectionorreactivationofalatentCMVinfection.CMVIgMantibodycanbedetectedbyELISAinbothprimaryCMVinfections(93-100%)andinreactivatedinfection(40%).AnIgMresponsemaybereducedorabsentinimmunocompromisedpatientswithactiveinfection.IntransplantpatientstheCMVinfectioncanbeassociatedwithhighermorbidityandmortality.
Reactivity	Human