Description:

Description:Dipeptidylpeptidase-4(DPP4),alsoknownasadenosinedeaminasecomplexingprotein2orCD26(clusterofdifferentiation26)isaproteinthat,inhumans,isencodedbytheDPP4gene.ThesubstratesofCD26/DPP4areproline(oralanine)containingpeptidesandincludegrowthfactors,chemokines,neuropeptides,andvasoactivepeptides.DPP4playsamajorroleinglucosemetabolism.ItisresponsIBLeforthedegradationofincretinssuchasGLP-1andhenceitsinhibitionbydrugssuchasSitagliptinhavebeenusedfortreatmentofdiabetesmellitustype2.DPP4alsoappearstoworkasasuppressorinthedevelopmentofcancerandtumors.InGenWay"sDPP4ActivityAssayKit,DPP4cleavesasubstratetoreleaseaquenchedfluorescentgroup,AMC(7-Amino-4-MethylCoumarin),(Ex/Em=360/460nm).Thisassayisrapid,simple,sensitive,andreliable,aswellas,suitableforhighthroughputactivityscreeningofDPP4.ThiskitdetectsDPP4activityaslowas3µUperwell.
Summary:
-Detectionmethod-Fluorescence(Ex/Em360/460nm)
-Sampletype-CellandTissueculturelysatess,plasma,serum,otherBIOLOGicalfluids,cellculturemediumetc.
-Speciesreactivity-Mammalian
-Applications-ThiskitdetectsDPP4activityaslowas3µUperwell.
Kitcomponents:
-DPP4AssayBuffer
-DPP4Substrate(H-Gly-Pro-AMC)
-DPP4PositiveControl
-AMCStandard(10µM)
-DPP4Inhibitor(Sitagliptin)
FeaturesandBenefits:
-Simpleprocedure;takes~40minutes
-Fastandconvenient
-Sensitive,reliableHTSassay
ShippingConditions:Gelpack

AdditionalInformation:

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Name	DPP4ActivityAssayKit
RelatedProductNames	DPP4assay
Format	AssayKit
Storage	-20C
IntendedUse	ResearchUseOnly