Description:

Transforming growth factor alpha(TGF-alpha) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects. TGFalpha stimulates neural cell proliferation in the adult injured brain. Transforming growth factor alpha gene(TGFA) maps to human chromosome 2 close to the breakpoint of the t(2;8) variant translocation in Burkitt lymphoma. Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells; the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic human TGF-alpha showed similar immunoreactivity when compared with rat TGF-alpha. Thus, the 50-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines.

Additional Information:

Name	Human TGF alpha ELISA Kit
Related Product Names	EGF like TGF|ETGF|OTTHUMP00000203300|OTTHUMP00000203301|OTTHUMP00000203345|OTTHUMP00000203352|Protransforming growth factor alpha|RATTGFAA|TFGA|TGF A|TGF type 1|TGFA|Transforming growth factor alpha|Transforming growth factor alpha precurso
Short Description	Sandwich ELISA kit of Quantitative Detection for Human TGF alpha
Immunogen	please inquire
Standard Range	15.6pg/ml-1000pg/ml. Test has a sensitivity of < 1="">
Sample Type	This kit is used for quantitative detection of human TGF alpha in cell culture supernates, serum, plasma(heparin, EDTA) and human milk.
Specimen/Volumes	Refer to Manual
Swiss Prot Number	P01135
Concentration	Lot Specific
Applications	ELISA
GI Number	7039
Stability	Four months at 4C and eight months at -20C.
Reactivity	Reactive to Human. There is cross-reactivates with TGF beta 2, TGF beta 3, TGF beta 5<>
Kit Size	1x96 well plate
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Intended Use	Research Use Only

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