Description:

Fibronectin(FN) also known as LETS, is identified on the surfFN of fibroblasts by labeling with radioactive compounds or specific antibodies. Fibronectin is a 430,000-dalton dimeric glycoprotein that exists in 2 forms, termed cellular and plasma fibronectin. Cellular and plasma fibronectins are heterodimers consisting of similar but not identical polypeptides. These two forms of FN differ in biologic activity. Fibronectins bind cell surfFNs and various compounds including collagen, fibrin, heparin, DNA, and actin. Because fibronectin stimulates endocytosis in several systems and promotes the clearance of particulate material from the circulation, it could function in the clearance of C1q-coated material such as immune complexes or cellular debris. Fibronectins are involved in cell adhesion, cell motility, opsonization, would healing, and maintenance of cell shape. LETS, encoded on chromosome 8, is responsible for the LETS protein expression in humans. Because LETS has been implicated in tumorigenicity and cellular transformation, it is of interest that rearrangement or modifications in the number of chromosome 8 have been associated with certain forms of cancer.

Additional Information:

Name	Mouse Fibronectin ELISA Kit
Related Product Names	CIG|Cold insoluble globulin|Fibronectin 1|FINC|FN|FN1|FNZ|Migration stimulating factor|MSF
Short Description	Sandwich ELISA kit of Quantitative Detection for Mouse Fibronectin
Immunogen	from plasma
Standard Range	156pg/ml-10,000pg/ml. Test has a sensitivity of < 15="">
Sample Type	This kit is used for quantitative detection of mouse Fibronectin in cell culture supernates, serum and plasma(heparin, EDTA, citrate).
Specimen/Volumes	Refer to Manual
Swiss Prot Number	P09055
Concentration	Lot Specific
Applications	ELISA
GI Number	16412
Stability	Four months at 4C and eight months at -20C.
Reactivity	Reactive to Mouse. There is no detectable cross-reactivity with other relevant proteins.
Kit Size	1x96 well plate
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
Intended Use	Research Use Only

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