PEGylated Liposomal Irinotecan HCl
Irinotecan HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is ofhigh quality withnarrow particle size distribution and high drug encapsualtion efficiency.
Product For Research only and NOT for Human Use
Specifications
Product code: F30204S-IT
Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5mol/mol)
Lipid concentration: 20.0 mM
Iroinotecan HCl: 2.0 mg/mL
Encapsulation efficiency: > 95% (typically 98%)
Loading battery: 250 mMammonium sulfate
Mean particle size:100 nm (80-110 nm)
External solution: 10% sucrose, 20 Mm HEPES, pH 7.0
Shelf-life:3 months, storage:2-8 degree C
Irinotecan:Synonym: (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl ester, CPT-11, [1,4′-Bipiperidine]-1′-carboxylic acid
CAS Number 100286-90-6,Empirical Formula: C33H38N4O6 · HCl, Sigma Cat#I1406
HSPC: hydrogenated phosphatidylcholine (Soy)
CHOL: cholesterol
mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
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