General Information

Product

5HT2C Receptor Antibody

Description

Affinity Purified 5-hydroxytryptamine receptor 2C Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-458 on human 5-hydroxytryptamine receptor 2C.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunocytochemistry

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P28335

Overview

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Multi-pass membrane protein

Expression

Detected in brain.

Structure

The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.

Alternative Nomenclature

5 Hydroxytryptamine 2C receptor antibody5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled antibody5-hydroxytryptamine receptor 1C antibody5-hydroxytryptamine receptor 2C antibody5HT1C antibody5HT2C antibody5HTR2C antibody5Hydroxytryptamine 2C receptor antibodyHtr1c antibodyHTR2C antibodyserotonin 1c receptor antibodyserotonin 2c receptor antibodySerotonin receptor 2C antibody