General Information

Product

CCR4 Antibody

Description

Affinity Purified C-C chemokine receptor type 4 Antibody

Verified Applications

CF, DB, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.

Accession #

NCBI: NP_005499

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P51679

Overview

Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC. Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates. Can also mediate hippocampal-neuron survival.

Molecular Function

GPCR, Receptor, Transducer.

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets. Expressed less in spleen and in monocytes. Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen. Expressed in brain and microvascular and coronary artery endothelial cells.

Structure

Belongs to G-protein coupled receptor 1 family. Interacts with CREB3.

Alternative Nomenclature

CD194 antibody

ChemR13 antibody

CKR4 antibody

CMKBR 4 antibody

HGCN 14099 antibody

K5 5 antibody