- SAHA (Vorinostat)
- 探测系统
- 雌酮ELISA试剂盒
- 成分辅助试剂
- PGFM ELISA试剂盒
- Triiodothyronine (T3) ELISA Kit
- Pregnanediol-3-Glucuronide (PDG) ELISA Kit
- 别孕孕酮ELISA试剂盒
- 左炔诺孕酮（LNG）ELISA试剂盒
- Corticosterone Chemiluminescent ELISA Kit
- BRL-50481
- DHEA-S ELISA Kit
- 甲状腺素（T4）ELISA试剂盒
- BML-278
- IBMX
- Testosterone ELISA Kit
- IOX1型
- 谷胱甘肽比色反应杯检测试剂盒
- 心钠素ELISA试剂盒
- Sirtinol
- Retinol Binding Protein (RBP) Multi-Format ELISA Kit
- MultiSpecies
- Histonedeacetylaseinhibitor
- Anti-cancer,-inflammatory,neuroprotectiveeffects
- DecreasesAbetaproduction
Ananticonvulsantusedinthetreatmentofepilepsy,anorexianervosa,panicattack,anxietydisorder,posttraumaticstressdisorder,migraineandbipolardisorder.Valproateisalsoahistonedeacetylaseinhibitor(IC50=400uM)thatexhibitsanticancer,anti-inflammatoryandneuroprotectiveeffects.DisplaysanticonvulsiveactivityviaanincreaseinGABAlevelsanddecreasesAbetaproductioninanimalmodelsofAlzheimer’sdisease.AlsoattenuatesNMDA-mediatedexcitation,blocksvoltage-gatedNa+channelsandmodulatesfiringofneurons.Enablesinduction ofpluripotentstemcellsfromsomaticcellsbyOct4andSox2.Valproicacidalsoinhibitsglycogensynthasekinase3(GSK3)anddepletescellularinositol-1,4,5-trisphosphate(1,4,5-IP3).ValproicacidshowspromiseincombinationtherapyforcancerandintreatingAlzheimer’sdisease.InhibitsClassIHDACswithanIC50valueof~2mM.
