The DetectX^® Dehydroepiandrosterone sulfate (DHEA-S) Immunoassay Kit uses a specifically generated antibody to measure DHEA-S in serum, plasma, urine, and saliva samples. The kit will also measure DHEA-S present in fecal extracts and tissue culture media samples.  Standards or diluted samples are pipetted into a clear microtiter plate coated with an antibody to capture sheep antibodies. A DHEA-S-peroxidase conjugate is added to the standards and samples in the wells. The binding reaction is initiated by the addition of a polyclonal antibody to DHEA-S to each well. After a 2 hour incubation the plate is washed and substrate is added. The substrate reacts with the bound DHEA-S-peroxidase conjugate. The intensity of the generated color is detected in a microtiter plate reader at 450nm.

DHEA-S is primarily produced by the adrenal glands and it is useful as a marker for adrenal function. Adrenal tumors, cancers, and hyperplasia can lead to the overproduction of DHEA-S. High DHEA-S levels can lead to amenorrhea and visible symptoms of virilization. These changes vary in severity and may include: a deeper voice, hirsutism, male pattern baldness, muscularity, acne and enlargement of the Adam’s apple. Women with polycystic ovary syndrome tend to have elevated levels of DHEA-S. Excess levels of DHEA-S in children can cause precocious puberty in boys; and ambiguous external genitalia, excess body hair, and abnormal menstrual periods in girls.

Arbor Assays的员工在仅用于研究目的和FDA体外诊断市场的设计，开发，构建和制造测定法方面拥有超过50年的综合经验。我们绝不妥协质量。在整个网站上，您会在几个页面上看到“ N-Cal™”字样。这是指将标准品校准至WHO或美国国家标准技术研究院（NIST）参考材料的试剂盒。任何套件都仅与参考的标准一样好。