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商品描述
| Product Name | 14-3-3 eta, 1-246aa, Human |
|---|---|
| Background | 14-3-3 eta also as known as YWHAH. This protein belong to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 eta interacts with and relocalizes the A20 zinc finger protein from the insoluble to the soluble fraction, suggesting a chaperone function. It implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binding to a large number of partners, usually by recognition of a phosphothreonine motif. Recombinant Human 14-3-3 eta was expressed in E.coli and purified by using conventional chromatography techniques. |
| Species | Human |
| Synonyms | YWHAH, YWHA1 |
| Host | E.coli |
| AA Sequence | MGDREQLLQR ARLAEQAERY DDMASAMKAV TELNEPLSNE DRNLLSVAYK NVVGARRSSW RVISSIEQKT MADGNEKKLE KVKAYREKIEKELETVCNDV LSLLDKFLIK NCNDFQYESK VFYLKMKGDY YRYLAEVASG EKKNSVVEAS EAAYKEAFEI SKEQMQPTHP IRLGLALNFS VFYYEIQNAP EQACLLAKQA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDE EAGEGN |
| Molecular Weight | 21.8kDa (192aa)28-40kDa (SDS-PAGE under reducing conditions) |
| Form | Liquid, in Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Concentration | 0.5mg/ml (determined by Absorbance at 280nm) |
| Purity | > 90% by SDS-PAGE |
| Applications | SDS-PAGE |
| NCBI | NP_003396 |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
| Intended Use | For Research Use Only |
| References | Maksymowych WP., et al. (2014) Arthritis Res Ther. 16(2): R99.Sato S., et al. (2002) J Biol Chem. 277: 39360-39367 |
