Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. The PI3K p85 subunit family has two closely related members, alpha and beta. Both cDNAs encode p85 subunits, each of which is a 724-amino acid polypeptide. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.
Titration of the PI3K antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 65-80 (ERGDFPGTYVEYIGRK-alpha subunit specific) was used as the immunogen for this PI3K antibody (100% human, mouse and rat).
Store the lyophilized PI3K antibody at4oC.After reconstitution, aliquot and store at -20oC.Avoid repeated freezing and thawing.