Caspase-12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The CASP12 gene was mapped to chromosome 11q22.3. Caspase-12 attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis. The estrogen-mediated inhibition of its expression is a built-in mechanism that has evolved to protect females from infection by favoring a more robust inflammatory response to pathogens, perhaps notably in childbirth.
The stated application concentrations are suggested starting points.Titration of the Caspase-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 71-84 (KIFREHLWNSKKQL-human) were used as the immunogen for this Caspase-12 antibody.
After reconstitution, the Caspase-12 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.
