Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. This protein belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells.
The stated application concentrations are suggested starting points. Titration of the NKG2A antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 180-206 from the human protein were used as the immunogen for the NKG2A antibody.
Aliquot the NKG2A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
