Specificity
HYB 245-01 is specific for human SP-D.
Immunogen
Recombinant neck CRD SP-D
Positive Species Reactivity
Human
Negative Species Reactivity
Not determined
Epitope Specificity
Not determined
Unit Size
200 µL: Cat. No. HYB 245-01-021 mL: Cat. No. HYB 245-01-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein A/G purified (from culture supernatant)
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Conjugation
Unconjugated BSA free
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Surfactant protein D (SP-D) is synthesized and secreted by lung epithelial cells. It belongs to group III ofthe family of C-type lectins and members of this group has overall structure consisting of multipleglobular "head" regions linked by triple-helical, collagen-like, strands. This group also includes SP-A andthe serum proteins mannan-binding protein, conglutinin and collectin-43, all of which have been shownto bind to the C1q receptor found on a wide variety of cells. Both SP-D and SP-A have been shown toenhance oxygen radical production by alveolar macrophages. The serum concentration is 88 ng/ml inhealthy individuals. (1)
bioporto的NGAL Test™是一种颗粒增强的浊度免疫测定法，用于在自动化临床化学分析仪上定量测定人尿液，EDTA血浆或肝素血浆中的与中性粒细胞明胶酶相关的脂蛋白（NGAL）。NGAL Test™校准器套件包含用于建立校准曲线的校准器解决方案。NGAL测量可用于诊断可能导致急性肾衰竭的急性肾损伤。
