OVERVIEW:

Synonyms	Monoclonal CAMLG antibody, Anti-CAMLG antibody, CAML antibody, MGC163197 antibody
Cross Reactivity	Human
Applications	FC, IF, WB
Immunogen	CAMLG antibody was raised in Mouse using full length human recombinant protein of human CAMLG produced in HEK293T cell as the immunogen.

SPECIFICATIONS:

Host	Mouse
Clone	2H3
Isotype	IgG1
Method of Purification	CAMLG antibody was purified by affinity chromatography.
Form & Buffer	Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5-1 mg/ml

STORAGE & SAFETY:

Storage	Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

Usage Assay Information:

Usage Recommendations	FC: 1:100, IF: 1:100, WB: 1:2000

GENERAL INFORMATION:

Biological Significance

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

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